Corneal Scheimpflug topography values to distinguish between normal eyes, ocular allergy, and keratoconus in children

• Published in: Scientific reports Vol. 11; no. 1; pp. 24275 - 10
• Main Authors: Vieira, Matheus Ivan Schmitz, Jammal, Alessandro Adad, Arieta, Carlos Eduardo Leite, Alves, Monica, de Vasconcellos, Jose Paulo Cabral
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/3161/3163; 692/700/1720/3187; Allergies; Area Under Curve; Astigmatism; Brazil; Child; Children; Cornea; Cornea - physiology; Corneal Topography - methods; Cross-Sectional Studies; Diagnosis, Differential; Female; Healthy Volunteers; Humanities and Social Sciences; Humans; Hypersensitivity - diagnosis; Keratoconus; Keratoconus - diagnosis; Male; Medical records; multidisciplinary; Multivariate Analysis; Odds Ratio; Prospective Studies; Regression Analysis; Risk Factors; ROC Curve; Science; Science (multidisciplinary); Sensitivity and Specificity; Topography; Brazil
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-03818-3

To identify and compare keratometric, corneal thickness, and elevation parameters and indices among healthy children, ocular allergy, and keratoconus using the OCULUS Pentacam Scheimpflug topography system. This study included healthy children, children with ocular allergy (OA) without keratoconus, and children with keratoconus (KC). The study design consisted of a prospective evaluation and review of medical records from a Brazilian ophthalmology department. The exclusion criteria were inability to undergo the ocular exam, other ocular diseases, contact lens wear, and topographic corneal ectasia. The effect of each corneal parameter was evaluated using univariate and multivariate logistic regression models adjusted for sex and age, and ROC curves were used to assess the ability each variable to discriminate among groups. A total of 182 subjects were included: healthy children (n = 99), children with OA (n = 32), and children with KC (n = 51). Groups differed in terms of sex, with more males in the OA group (73.2%) and the KC group (67.7%) than in the control group (40.9%). All corneal parameters studied differed significantly between the control and KC groups, and between the OA and KC groups; they also differed significantly between the three groups in terms of astigmatism, q-value, CCT, TP, BAD-D, and ARTmax values. We present the first study to describe and compare corneal tomographic parameters in healthy children, OA, and KC. Keratometry indices, ACD, ARTmax, AETP, and PETP were found to be the most useful for differentiating between healthy and KC children. IBR registry number: CAAE 54921916.9.0000.5404.