Neuropsychological Detection of the Early Stage of Amnestic Mild Cognitive Impairment without Objective Memory Impairment

• Published in: Dementia and geriatric cognitive disorders Vol. 35; no. 1-2; pp. 98 - 105
• Main Authors: Murayama, Norio, Tagaya, Hirokuni, Ota, Kazumi, Fujishiro, Hiroshige, Manabe, Yuta, Sato, Kiyoshi, Isek, Eizo
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2013; S. Karger AG
• Subjects: Aged; Amnesia - diagnosis; Amnesia - pathology; Amnesia - psychology; Analysis of Variance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - pathology; Cognitive Dysfunction - psychology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care; Female; Fluorodeoxyglucose F18; Humans; Intelligence Tests; Intensive care medicine; Japan; Logistic Models; Magnetic Resonance Imaging; Male; Medical sciences; Memory - physiology; Middle Aged; Neurology; Neuropsychological Tests; Original Research Article; Positron-Emission Tomography; Radiopharmaceuticals; ROC Curve; Wechsler Scales; Wechsler Adult Intelligence Scale; Early diagnosis; Wechsler Memory Scale; Alzheimer’s disease; Neuropsychological assessment; Mild cognitive impairment; Memory disorder; Nervous system diseases; Memory Scale Wechsler; Cognitive disorder; Alzheimer disease; Early stage; Medical screening; Cerebral disorder; Central nervous system disease; mild cognitive impairment; Degenerative disease; Diagnosis; Alzheimer's disease; Adult Intelligence Scale Wechsler
• ISSN: 1420-8008; 1421-9824
• DOI: 10.1159/000346286

Aim: We investigate the assessment method to detect the early stage of amnestic mild cognitive impairment (aMCI) using Wechsler Memory Scale – Revised (WMS-R) and Wechsler Adult Intelligence Scale – Third Edition (WAIS-III). Methods: Three groups (normal group, aMCI group, and early aMCI group), controlled for age and years of education, underwent brain 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET), WAIS-III, WMS-R, and other tests. The early aMCI group does not fulfill the clinical diagnostic criteria of aMCI because patients do not have objective memory impairment, but their clinical symptoms and results of 18 F-FDG PET indicate that they should be included in the category of aMCI. Results: The discrepancy of scores between Verbal IQ and General Memory had the highest accuracy in discriminating between normal and early aMCI groups. Conclusion: The cutoff point determined in this study is useful to detect an early stage of aMCI, which may be distinguished from aMCI using the current criteria.