Silkworm silk-based materials and devices generated using bio-nanotechnology
Silks are natural fibrous protein polymers that are spun by silkworms and spiders. Among silk variants, there has been increasing interest devoted to the silkworm silk of B. mori , due to its availability in large quantities along with its unique material properties. Silk fibroin can be extracted fr...
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| Published in | Chemical Society reviews Vol. 47; no. 17; pp. 6486 - 654 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
28.08.2018
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Silks are natural fibrous protein polymers that are spun by silkworms and spiders. Among silk variants, there has been increasing interest devoted to the silkworm silk of
B. mori
, due to its availability in large quantities along with its unique material properties. Silk fibroin can be extracted from the cocoons of the
B. mori
silkworm and combined synergistically with other biomaterials to form biopolymer composites. With the development of recombinant DNA technology, silks can also be rationally designed and synthesized
via
genetic control. Silk proteins can be processed in aqueous environments into various material formats including films, sponges, electrospun mats and hydrogels. The versatility and sustainability of silk-based materials provides an impressive toolbox for tailoring materials to meet specific applications
via
eco-friendly approaches. Historically, silkworm silk has been used by the textile industry for thousands of years due to its excellent physical properties, such as lightweight, high mechanical strength, flexibility, and luster. Recently, due to these properties, along with its biocompatibility, biodegradability and non-immunogenicity, silkworm silk has become a candidate for biomedical utility. Further, the FDA has approved silk medical devices for sutures and as a support structure during reconstructive surgery. With increasing needs for implantable and degradable devices, silkworm silk has attracted interest for electronics, photonics for implantable yet degradable medical devices, along with a broader range of utility in different device applications. This Tutorial review summarizes and highlights recent advances in the use of silk-based materials in bio-nanotechnology, with a focus on the fabrication and functionalization methods for
in vitro
and
in vivo
applications in the field of tissue engineering, degradable devices and controlled release systems.
Silks are natural fibrous protein polymers that are spun by silkworms and spiders. This
tutorial review
summarizes and highlights recent advances in the use of silkworm silk-based materials in bio-nanotechnology. |
|---|---|
| Bibliography: | Dr Chunmei Li obtained her PhD in Chemical Engineering at Tufts University. After her postdoc training at Swiss Federal Institute of Technology at Zurich (ETH) and Tufts University, she is currently a research assistant professor in biomedical engineering department at Tufts university. Her research interests focus on the development of biomaterials for various biomedical applications, specifically novel protein-based materials for orthopedic application, biomaterials to regulate immune response, as well as scaffolding materials to create complex tissue microstructures. Prof. Fiorenzo G. Omenetto is the Frank C. Doble Professor of Engineering, and a Professor of Biomedical Engineering at Tufts University. He also holds appointments in the Department of Physics and the Department of Electrical Engineering. His research interests are at the interface of technology, biologically inspired materials and the natural sciences with an emphasis on new transformative approaches for sustainable materials for high-technology applications. He also serves as Dean for Research for the School of Engineering. Dr Shengjie Ling is an assistant professor in School of Physical Science and Technology at ShanghaiTech University. He is also a research affiliate at MIT and Tufts University. He obtained his BS from the Zhejiang University of Technology (2009) and PhD from Fudan University (2014). During 2012-2013, He awarded the State Scholarship Fund to pursue his study at ETH Zurich, Switzerland, as a joint PhD student. He did a postdoc training at MIT and Tufts University before joining ShanghaiTech University in September 2017. Prof. David Kaplan holds an Endowed Chair, the Stern Family Professor of Engineering, at Tufts University. He is Professor & Chair of the Department of Biomedical Engineering and also holds faculty appointments in the School of Medicine, the School of Dental Medicine, Department of Chemistry and the Department of Chemical and Biological Engineering. He directs the NIH P41 Tissue Engineering Resource Center (TERC) that involves Tufts University and Columbia University and is Editor for the ACS Biomaterials Science and Engineering. Dr Wenwen Huang is a postdoctoral associate in a joint program between the Department of Biomedical Engineering at Tufts University and Civil and Environmental Engineering at MIT, with the financial support of NIH. She received her bachelor's degree in Physics from Peking University, Beijing, China, and her PhD in Physics from Tufts University. Her research interests include genetic engineering of hierarchical and stimuli-responsive proteins, physical and chemical modification of protein-based materials, as well as protein self-assembly mechanisms. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c8cs00187a |