Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia

• Published in: American journal of obstetrics and gynecology Vol. 203; no. 4; pp. 366.e1 - 366.e6
• Main Authors: Robinson, Christopher J., Alanis, Mark C., Wagner, Carol L., Hollis, Bruce W., Johnson, Donna D.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2010; Elsevier
• Subjects: 25-hydroxyvitamin D; Adult; adverse pregnancy outcome; African Continental Ancestry Group; Biological and medical sciences; Case-Control Studies; Diseases of mother, fetus and pregnancy; European Continental Ancestry Group; Female; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Obstetrics and Gynecology; Pre-Eclampsia - blood; preeclampsia; Pregnancy; Pregnancy. Fetus. Placenta; Radioimmunoassay; Severity of Illness Index; vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - diagnosis; adverse pregnancy outcome; preeclampsia; 25-hydroxyvitamin D; vitamin D; Pregnancy disorders; Gynecology; Preeclampsia; Early; Obstetrics; Pregnancy toxemia; Blood plasma
• ISSN: 0002-9378; 1097-6868; 1097-6868
• DOI: 10.1016/j.ajog.2010.06.036

Vitamin D deficiency has been linked to adverse pregnancy outcomes. The purpose of this investigation was to assess total 25-hydroxyvitamin D (25-OH-D) levels at diagnosis of early-onset severe preeclampsia (EOSPE). After institutional review board approval, we enrolled subjects with EOSPE (<34 weeks' gestation with severe preeclampsia) in this case-control investigation in a 1:2 ratio with gestation-matched, contemporaneous control subjects. Demographic and outcome information was collected for each subject. Plasma total 25-OH-D levels were determined by radioimmunoassay and reported in nanograms per milliliter. Results were analyzed by Mann-Whitney U and multivariable regression. Subjects with EOSPE (n = 50) were noted to have decreased total 25-OH-D levels relative to healthy control subjects (n = 100; P < .001). This difference in total 25-OH-D remained significant after control for potential confounders. Total 25-OH-D is decreased at diagnosis of EOSPE. Further study is needed to understand the impact of vitamin D deficiency on pregnancy outcomes.