In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy

Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to estab...

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Bibliographic Details
Published inJournal of biomedical optics Vol. 13; no. 5; p. 050504
Main Authors Laubach, Hans-Joachim, Chang, Sung K, Lee, Seonkyung, Rizvi, Imran, Zurakowski, David, Davis, Steven J, Taylor, Charles R, Hasan, Tayyaba
Format Journal Article
LanguageEnglish
Published United States 01.09.2008
Subjects
Aminolevulinic Acid - administration & dosage
Female
Humans
Luminescent Measurements - methods
Male
Photochemotherapy - methods
Photosensitizing Agents - administration & dosage
Radiometry - methods
Singlet Oxygen - analysis
Skin - drug effects
Skin - metabolism
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Summary:Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response.
ISSN:1083-3668
DOI:10.1117/1.2981813