Antidyslipidemic and antioxidant activity of an unusual amino acid (2-amino-5-hydroxyhexanoic acid) isolated from the seeds of Crotalaria juncea

• Published in: Phytomedicine (Stuttgart) Vol. 21; no. 1; pp. 15 - 19
• Main Authors: Prasad, Janki, Singh, Vinay Kr, Shrivastava, Atul, Chaturvedi, Upma, Bhatia, Gitika, Arya, K.R., Awasthi, S.K., Narender, T.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 15.12.2013; Urban & Fischer Verlag
• Subjects: Animals; Anticholesteremic agents; Antidyslipidemic activity; Antioxidant activity; Antioxidants; Antioxidants - isolation & purification; Antioxidants - pharmacology; Antioxidants - therapeutic use; Caproates - isolation & purification; Caproates - pharmacology; Caproates - therapeutic use; Crotalaria - chemistry; Crotalaria juncea; Dose-Response Relationship, Drug; Health aspects; Hyperlipidemias - blood; Hyperlipidemias - chemically induced; Hyperlipidemias - drug therapy; Hypolipidemic Agents - isolation & purification; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; Lipids - blood; Medicinal plants; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rats; Seeds - chemistry; Triton model; India; Triton model; Crotalaria juncea; Antidyslipidemic activity; Antioxidant activity
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1016/j.phymed.2013.08.004

In continuation of our drug discovery programme on Indian medicinal plants, we isolated an unusual amino acid, i.e. 2-amino-5-hydroxyhexanoic acid (1) from the seeds of Crotalaria juncea. The 2-amino-5-hydroxyhexanoic acid (1) showed dose dependent lipid lowering activity in the in vivo experiments and also showed good in vitro antioxidant activity. The cyclized compound, 3-amino-6-methyltetrahydro-2H-pyran-2-one (2) showed better lipid lowering and antioxidant profile than the parent compound 1.