Antidyslipidemic and antioxidant activity of an unusual amino acid (2-amino-5-hydroxyhexanoic acid) isolated from the seeds of Crotalaria juncea
In continuation of our drug discovery programme on Indian medicinal plants, we isolated an unusual amino acid, i.e. 2-amino-5-hydroxyhexanoic acid (1) from the seeds of Crotalaria juncea. The 2-amino-5-hydroxyhexanoic acid (1) showed dose dependent lipid lowering activity in the in vivo experiments...
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Published in | Phytomedicine (Stuttgart) Vol. 21; no. 1; pp. 15 - 19 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Elsevier GmbH
15.12.2013
Urban & Fischer Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | In continuation of our drug discovery programme on Indian medicinal plants, we isolated an unusual amino acid, i.e. 2-amino-5-hydroxyhexanoic acid (1) from the seeds of Crotalaria juncea. The 2-amino-5-hydroxyhexanoic acid (1) showed dose dependent lipid lowering activity in the in vivo experiments and also showed good in vitro antioxidant activity. The cyclized compound, 3-amino-6-methyltetrahydro-2H-pyran-2-one (2) showed better lipid lowering and antioxidant profile than the parent compound 1. |
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Bibliography: | http://dx.doi.org/10.1016/j.phymed.2013.08.004 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0944-7113 1618-095X |
DOI: | 10.1016/j.phymed.2013.08.004 |