Hedgehog Signaling in Development and Cancer

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted r...

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Bibliographic Details
Published inDevelopmental cell Vol. 15; no. 6; pp. 801 - 812
Main Authors Jiang, Jin, Hui, Chi-chung
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Inc 01.12.2008
Cell Press
Subjects
Animals
Biological and medical sciences
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cell Proliferation
Drosophila
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic
Hedgehog Proteins - metabolism
Humans
Models, Biological
Molecular and cellular biology
Neoplasms - metabolism
Neurons - metabolism
Signal Transduction
Stem Cells - cytology
Development
Malignant tumor
Cell signaling
Cancer
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Summary:The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2008.11.010