Cardiac perforation after device closure of atrial septal defects with the Amplatzer septal occluder

• Published in: Journal of the American College of Cardiology Vol. 45; no. 8; pp. 1213 - 1218
• Main Authors: Divekar, Abhay, Gaamangwe, Tidimogo, Shaikh, Nasir, Raabe, Michael, Ducas, John
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 19.04.2005; Elsevier Science; Elsevier Limited
• Subjects: Adult; Aorta - injuries; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Coronary vessels; Drug therapy; Female; Heart; Heart Atria - injuries; Heart attacks; Heart Injuries - etiology; Heart Septal Defects, Atrial - therapy; Hospitalization; Humans; Intubation; Medical equipment; Medical sciences; Prostheses and Implants - adverse effects; ASD; CE; FDA; SBD; TEE; PFO; MAUDE; ASO; CP; Heart; Closure; Malformation; Perforation; Heart disease; Device; Atrial septal defect; Instrumentation therapy; Cardiovascular disease; Intracardiac defect; Instrumental obliteration; Congenital disease
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2004.12.072

Amplatzer septal occluder (ASO)-associated cardiac perforation (CP) at our institution prompted this retrospective review. Cardiac perforation is a rare complication after transcatheter atrial septal defect (ASD) closure. To identify CP after transcatheter ASD closure with ASO, cardiac events (CE) describing definite CP, hemopericardium, pericardial effusion, cardiovascular collapse, or sudden death were analyzed. Cardiac events were identified from published literature (MEDLINE), medical device regulating agencies in North America and the European Commission, and AGA Medical Corporation (Golden Valley, Minnesota). Institutional cases were reviewed. Cardiac events were defined as early (pre-discharge) or late (post-discharge). Twenty-nine CEs were identified. Five were excluded because findings were inconclusive for device-related CP. Ten patients were <18 years of age. Late CEs occurred in 66.6%; 25% presented weeks later (longest, three years). Three deaths were reported. Cardiac perforation occurred predominantly in the anterosuperior atrial walls and/or adjacent aorta. Amplatzer septal occluder-associated CP uniquely involves the anterosuperior atrial walls and adjacent aorta. Pathophysiology remains poorly understood.