Radar Breaks the Fog: Insights into Dorsoventral Patterning in Zebrafish

Sidi et al have provided thrilling evidence that at least in the zebrafish embryo there may be no ventral default state at all. Sidi and collaborators identified a distinct TFG-beta ligand Radar as a part of the maternal dowry that activates the zygotic expression of bone morphogenetic protein genes...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 100; no. 8; pp. 4363 - 4365
Main Authors Wilm, Thomas P., Solnica-Krezel, Lilianna
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 15.04.2003
National Acad Sciences
The National Academy of Sciences
Subjects
Alleles
Animals
Body Patterning - genetics
Body Patterning - physiology
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 4
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins - genetics
Bone Morphogenetic Proteins - physiology
Bones
Commentaries
Embryos
Fish
Gene expression regulation
Gene Expression Regulation, Developmental
Genes
Growth Differentiation Factor 6
Ligands
Mesoderm
Models, Biological
Mutation
Phenotypes
Proteins
Radar
Receptors
Regulator genes
Signal Transduction
Transforming Growth Factor beta
Zebrafish - embryology
Zebrafish - genetics
Zebrafish Proteins
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Summary:Sidi et al have provided thrilling evidence that at least in the zebrafish embryo there may be no ventral default state at all. Sidi and collaborators identified a distinct TFG-beta ligand Radar as a part of the maternal dowry that activates the zygotic expression of bone morphogenetic protein genes and they start to delineate the pathway involved.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
To whom correspondence should be addressed. E-mail: lilianna.solnica-krezel@vanderbilt.edu.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0931010100