Zopiclone use associated with increased risk of acute pancreatitis: a case–control study in Taiwan
Summary Background The purpose of this study was to assess the relationship between zopiclone use and the risk of acute pancreatitis in Taiwan. Methods This was a population‐based case–control study. The data source was from the database of the Taiwan National Health Insurance Program since 2000–201...
Saved in:
Published in | International journal of clinical practice (Esher) Vol. 69; no. 11; pp. 1275 - 1280 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Hindawi Limited
01.11.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Summary
Background
The purpose of this study was to assess the relationship between zopiclone use and the risk of acute pancreatitis in Taiwan.
Methods
This was a population‐based case–control study. The data source was from the database of the Taiwan National Health Insurance Program since 2000–2011. We identified 5169 subjects aged 20–84 years with a first‐time attack of acute pancreatitis as the patients and 20,676 sex‐matched and age‐matched subjects without acute pancreatitis as the controls. Active use of zopiclone was defined as subjects who received at least one prescription for zopiclone within 30 days before the date of diagnosing acute pancreatitis. The lack of zopiclone prescription was defined as ‘never use’. We calculated the odds ratio (OR) and 95% confidence interval (CI) to assess the risk of acute pancreatitis associated with zopiclone use by the multivariable logistic regression model.
Results
After adjustment for potential confounding variables, the adjusted OR of acute pancreatitis was 2.36 for subjects with active use of zopiclone (95% CI 1.70–3.28), as compared with those with never use of zopiclone. In further analysis, as a reference of subjects with never use of zopiclone and without alcohol‐related disease and biliary stone, the adjusted OR increased to 14.44 in those with active use of zopiclone and with alcohol‐related disease or biliary stone (95% CI 7.47–27.89).
Conclusions
Subjects actively using zopiclone are associated with increased risk of acute pancreatitis. Clinicians should take acute pancreatitis risk into account when prescribing zopiclone, particularly comorbid with alcohol‐related disease or biliary stone. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1368-5031 1742-1241 |
DOI: | 10.1111/ijcp.12689 |