NEW ANTIBIOTICS FROM GENETICALLY ENGINEERED ACTINOMYCETES I. 2-NORERYTHROMYCINS, ISOLATION AND STRUCTURAL DETERMINATIONS

Novel macrolide antibiotics have been isolated from a genetically manipulated actinomycete. The major components produced have been isolated and identified as 2-norerythromycins A, B, C and D by mass spectrometry and extensive ID and 2D NMR experiments.

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Bibliographic Details
Published inJournal of antibiotics Vol. 40; no. 8; pp. 1115 - 1122
Main Authors GREENER, KEVIN D., MCALPINE, JAMES B., TUAN, JAMES S., KATZ, LEONARD, WHITTERN, DAVID N., BUKO, ALEX, BROWN, DAVID P.
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1987
Japan Antibiotics Research Association
Subjects
2-norerythromycins
Actinomycetaceae - analysis
Actinomycetaceae - genetics
Anti-Bacterial Agents - isolation & purification
Antibiotics
Biological and medical sciences
Biotechnology
Erythromycin - analogs & derivatives
Fundamental and applied biological sciences. Psychology
General pharmacology
Genetic Engineering
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
N.M.R
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Production of active biomolecules
Saccharopolyspora erythraea
Streptomyces - genetics
Streptomyces antibioticus
Isolation
Antibiotic
Genetic engineering
Molecular structure
Macrolide
Online AccessGet full text
ISSN0021-8820
1881-1469
DOI10.7164/antibiotics.40.1115

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Summary:Novel macrolide antibiotics have been isolated from a genetically manipulated actinomycete. The major components produced have been isolated and identified as 2-norerythromycins A, B, C and D by mass spectrometry and extensive ID and 2D NMR experiments.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.1115