Glucose to Fructose Isomerization in Aqueous Media over Homogeneous and Heterogeneous Catalysts

• Published in: ChemCatChem Vol. 8; no. 6; pp. 1100 - 1110
• Main Authors: Marianou, Asimina A., Michailof, Chrysoula M., Pineda, Antonio, Iliopoulou, Eleni F., Triantafyllidis, Kostas S., Lappas, Angelos A.
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 18.03.2016; Wiley Subscription Services, Inc
• Subjects: basic catalysts; Glucose; glucose isomerization; Lewis acid catalysts; MgO; sodium aluminate
• ISSN: 1867-3880; 1867-3899
• DOI: 10.1002/cctc.201501203

Isomerization of glucose to fructose is an important reaction with numerous applications in terms of biomass valorization. The reaction is catalyzed enzymatically but may also proceed under alkaline conditions, in which case it is accompanied by low selectivity and formation of byproducts. Solid Lewis acid and basic catalytic materials are being studied as alternative catalysts. In this work, the isomerization of glucose to fructose in aqueous media over homogeneous and heterogeneous catalysts has been investigated. The effect of polar aprotic solvents and their mixtures with water on glucose conversion and fructose selectivity was also studied. Sodium aluminate (NaAlO2) has been proven to be very effective, resulting in high fructose yield (52.1 %) and high selectivity (84.8 %). Among the various solid catalysts tested, MgO afforded glucose conversion of 44 %, with 75.8 % and 33.4 % fructose selectivity and yield, respectively, when the isomerization reaction was conducted in neat H2O. Homogeneous versus heterogeneous: The recyclable and reusable basic MgO catalyst with high fructose selectivity in glucose isomerization, offers a promising alternative to more reactive homogeneous catalysts such as NaAlO2.