Prediction for cardiovascular diseases based on laboratory data: An analysis of random forest model

• Published in: Journal of clinical laboratory analysis Vol. 34; no. 9; pp. e23421 - n/a
• Main Authors: Su, Xi, Xu, Yongyong, Tan, Zhijun, Wang, Xia, Yang, Peng, Su, Yani, Jiang, Yangyang, Qin, Sijia, Shang, Lei
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.09.2020; John Wiley and Sons Inc
• Subjects: Age; Blood pressure; Body mass index; Bronchitis; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Diabetes; Family medical history; Gender; High density lipoprotein; Hypertension; Laboratories; Population; prediction model; Prediction models; random forest; Regression analysis; Risk assessment; Risk factors; Software; Stroke; Tuberculosis; Variables
• ISSN: 0887-8013; 1098-2825; 1098-2825
• DOI: 10.1002/jcla.23421

Background To establish a prediction model for cardiovascular diseases (CVD) in the general population based on random forests. Methods A retrospective study involving 498 subjects was conducted in Xi'an Medical University between 2011 and 2018. The random forest algorithm was used to screen out the variables that greatly affected the CVD prediction and to establish a prediction model. The important variables were included in the multifactorial logistic regression analysis. The area under the curve (AUC) was compared between logistic regression model and random forest model. Results The random forest model revealed the variables, including the age, body mass index (BMI), fasting blood glucose (FBG), diastolic blood pressure (DBP), triglyceride (TG), systolic blood pressure (SBP), total cholesterol (TC), waist circumference, and high‐density lipoprotein‐cholesterol (HDL‐C), were more significant for CVD prediction; the AUC was 0.802 in CVD prediction. Multifactorial logistic regression analysis indicated that the risk factors for CVD included the age [odds ratio (OR): 1.14, 95% confidence intervals (CI): 1.10‐1.17, P < .001], BMI (OR: 1.13, 95% CI: 1.06‐1.20, P < .001), TG (OR: 1.11, 95% CI: 1.02‐1.22, P = .023), and DBP (OR: 1.04, 95% CI: 1.02‐1.06, P = .001); the AUC was 0.843 in CVD prediction. The established logistic regression prediction model was Logit P = Log[P/(1 − P)] = −11.47 + 0.13 × age + 0.12 × BMI + 0.11 × TG + 0.04 × DBP; P = 1/[1 + exp(−Logit P)]. People were prone to develop CVD at the time of P > .51. Conclusions A prediction model for CVD is developed in the general population based on random forests, which provides a simple tool for the early prediction of CVD.