Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can be prevalent even in early disease stages, affecti...

Full description

Saved in:
Bibliographic Details
Published inNeurology international Vol. 15; no. 3; pp. 1106 - 1116
Main Authors Doskas, Triantafyllos K., Christidi, Foteini, Spiliopoulos, Kanellos C., Tsiptsios, Dimitrios, Vavougios, George D., Tsiakiri, Anna, Vorvolakos, Theofanis, Kokkotis, Christos, Iliopoulos, Ioannis, Aggelousis, Nikolaos, Vadikolias, Konstantinos
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2023
MDPI
Subjects
Anxiety
Cognition & reasoning
Cognitive ability
cognitive impairment
Disability
Disease
Emotions
Executive function
fatigue
Memory
Mental depression
mood
Multiple sclerosis
Personal relationships
Protocol
Quality of life
social cognition
Social interaction
Verbal communication
Online AccessGet full text

Cover

More Information
Summary:Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can be prevalent even in early disease stages, affecting the physical activity and active social participation of PwMS. Limited information is available regarding the influence of MS in social cognition (SC), which may occur independently from the overall neurocognitive dysfunction. In addition, the available information regarding the factors that influence SC in PwMS is limited, e.g., factors such as a patient’s physical disability, different cognitive phenotypes, mood status, fatigue. Considering that SC is an important domain of CI in MS and may contribute to subjects’ social participation and quality of life, we herein conceptualize and present the methodological design of a cross-sectional study in 100 PwMS of different disease subtypes. The study aims (a) to characterize SC impairment in PwMS in the Greek population and (b) to unveil the relationship between clinical symptoms, phenotypes of CI, mood status and fatigue in PwMS and the potential underlying impairment on tasks of SC.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2035-8377
2035-8385
2035-8377
DOI:10.3390/neurolint15030068