The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM2.5-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings

Fine particulate matter 2.5 (PM 2.5 ) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM 2.5 -induced inflammatory responses in mother rats, and PM 2.5 -induced...

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Published inScientific reports Vol. 9; no. 1
Main Authors Tseng, Chia-Yi, Yu, Jia-Yu, Chuang, Yu-Chen, Lin, Chia-Ying, Wu, Chun-Hao, Liao, Chia-Wei, Yang, Fu-Hua, Chao, Ming-Wei
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 02.05.2019
Nature Publishing Group
Subjects
631/378/2571
692/617/375/366
Free radicals
Ganoderma
Hippocampus
Humanities and Social Sciences
Immunomodulation
Inflammation
miRNA
multidisciplinary
Neurological diseases
Offspring
Oxidative stress
Particulate matter
Rodents
Science
Science (multidisciplinary)
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Summary:Fine particulate matter 2.5 (PM 2.5 ) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM 2.5 -induced inflammatory responses in mother rats, and PM 2.5 -induced inflammatory responses and neurological damage in their offspring. The results suggested that GMI administration decreased the risk of neurological disorders in mother rats and their offspring by reducing the white blood cell count, lessening inflammatory responses and PM 2.5 -induced memory impairment, and preventing dendritic branches in the hippocampi from declining and microRNAs from PM 2.5 -induced modulation.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-38810-5