Bone-marrow mononuclear cell therapy of severe ischemic heart failure

• Published in: Comptes rendus. Biologies Vol. 330; no. 6; pp. 543 - 549
• Main Authors: Dohmann, Hans Fernando R., Silva, Suzana A., Souza, André L.S., Rossi, Maria Isabel D., Takiya, Christina M., Borojevic, Radovan
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Paris Elsevier SAS 01.06.2007; Elsevier
• Subjects: Agronomy. Soil science and plant productions; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Angiogenesis; Angiogenèse; Animals; Applied cell therapy and gene therapy; Biological and medical sciences; Bone marrow; Bone Marrow Transplantation; Cell therapy; Crise cardiaque; Electrophysiology; Fundamental and applied biological sciences. Psychology; General aspects; Heart failure; Humans; Ischemia; Ischémie; Medical sciences; Moelle osseuse; Myocarde; Myocardial Ischemia - therapy; Myocardium; Myocytes, Cardiac - transplantation; Thérapie cellulaire; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Heart failure; Angiogenesis; Thérapie cellulaire; Cell therapy; Ischemia; Myocarde; Angiogenèse; Myocardium; Bone marrow; Crise cardiaque; Ischémie; Moelle osseuse; Heart; Zoology; Cardiovascular disease; Biology; Crisis; Regeneration; Mononuclear cell; Treatment; Heart disease; Agriculture; Circulatory system; Neovascularization; Severe

We describe cell therapy for severe ischemic heart failure using transendocardial injection of autologous bone-marrow-derived mononuclear cells. The treated patients had significantly less heart failure and angina, sustained significant improvement of pumping power, exercise capacity, cardiac muscle...