Bone-marrow mononuclear cell therapy of severe ischemic heart failure
We describe cell therapy for severe ischemic heart failure using transendocardial injection of autologous bone-marrow-derived mononuclear cells. The treated patients had significantly less heart failure and angina, sustained significant improvement of pumping power, exercise capacity, cardiac muscle...
Saved in:
Published in | Comptes rendus. Biologies Vol. 330; no. 6; pp. 543 - 549 |
---|---|
Main Authors | , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Paris
Elsevier SAS
01.06.2007
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | We describe cell therapy for severe ischemic heart failure using transendocardial injection of autologous bone-marrow-derived mononuclear cells. The treated patients had significantly less heart failure and angina, sustained significant improvement of pumping power, exercise capacity, cardiac muscle irrigation, and blood supply to the body. Electrical and mechanical mappings of the myocardium before and after the therapy, and anatomopathological examination of the myocardium of one of the patients that had deceased of a stroke eleven months after the treatment indicated sustained neoangiogenesis and improvement of activity and quantity of cardiomyocytes in the injected regions. Post-hoc analyses of injected cell phenotype and improvement of myocardial function indicate that presence of CD8+ and CD56+ cells does not correlate with good prognostics, suggesting a possibility of cell selection. For ‘no-option’ severe cardiac patients, significant benefits of cell therapy and absence of adverse effects may justify the application of bone-marrow-derived cell therapy.
To cite this article: H.F.R. Dohmann et al., C. R. Biologies 330 (2007).
Nous décrivons la thérapie d'ischémies graves du myocarde par injections trans-endocardiques de cellules autologues mononucléaires de la moelle osseuse. Les malades traités ont montré une diminution significative de l'angine et une amélioration permanente de l'activité cardiaque, de la capacité d'exercice physique, d'irrigation du myocarde et de la circulation systémique. L'analyse de l'activité électrique et contractile du myocarde avant et quatre mois après la thérapie, ainsi que l'analyse anatomopathologique du cœur d'un des malades décédé onze mois après la thérapie à la suite d'un accident vasculaire cérébral, ont révélé une angiogenèse et une augmentation de l'activité et de la quantité de cardiomyocytes dans les régions traitées. L'analyse comparative des résultats du traitement et de la composition de cellules injectées a montré que la quantité de cellules CD8+ et CD56+ n'est pas associée au bon pronostic. Ce résultat peut indiquer une sélection de cellules de la moelle osseuse devant être injectées. Du fait de l'absence d'effets indésirables et du caractère significativement bénéfique du traitement décrit, les thérapies cellulaires peuvent dès à présent représenter une proposition raisonnable pour les malades à qui ne peut être offerte aucune autre thérapie.
Pour citer cet article : H.F.R. Dohmann et al., C. R. Biologies 330 (2007). |
---|---|
AbstractList | We describe cell therapy for severe ischemic heart failure using transendocardial injection of autologous bone-marrow-derived mononuclear cells. The treated patients had significantly less heart failure and angina, sustained significant improvement of pumping power, exercise capacity, cardiac muscle irrigation, and blood supply to the body. Electrical and mechanical mappings of the myocardium before and after the therapy, and anatomopathological examination of the myocardium of one of the patients that had deceased of a stroke eleven months after the treatment indicated sustained neoangiogenesis and improvement of activity and quantity of cardiomyocytes in the injected regions. Post-hoc analyses of injected cell phenotype and improvement of myocardial function indicate that presence of CD8+ and CD56+ cells does not correlate with good prognostics, suggesting a possibility of cell selection. For ‘no-option’ severe cardiac patients, significant benefits of cell therapy and absence of adverse effects may justify the application of bone-marrow-derived cell therapy.
To cite this article: H.F.R. Dohmann et al., C. R. Biologies 330 (2007).
Nous décrivons la thérapie d'ischémies graves du myocarde par injections trans-endocardiques de cellules autologues mononucléaires de la moelle osseuse. Les malades traités ont montré une diminution significative de l'angine et une amélioration permanente de l'activité cardiaque, de la capacité d'exercice physique, d'irrigation du myocarde et de la circulation systémique. L'analyse de l'activité électrique et contractile du myocarde avant et quatre mois après la thérapie, ainsi que l'analyse anatomopathologique du cœur d'un des malades décédé onze mois après la thérapie à la suite d'un accident vasculaire cérébral, ont révélé une angiogenèse et une augmentation de l'activité et de la quantité de cardiomyocytes dans les régions traitées. L'analyse comparative des résultats du traitement et de la composition de cellules injectées a montré que la quantité de cellules CD8+ et CD56+ n'est pas associée au bon pronostic. Ce résultat peut indiquer une sélection de cellules de la moelle osseuse devant être injectées. Du fait de l'absence d'effets indésirables et du caractère significativement bénéfique du traitement décrit, les thérapies cellulaires peuvent dès à présent représenter une proposition raisonnable pour les malades à qui ne peut être offerte aucune autre thérapie.
Pour citer cet article : H.F.R. Dohmann et al., C. R. Biologies 330 (2007). We describe cell therapy for severe ischemic heart failure using transendocardial injection of autologous bone-marrow-derived mononuclear cells. The treated patients had significantly less heart failure and angina, sustained significant improvement of pumping power, exercise capacity, cardiac muscle irrigation, and blood supply to the body. Electrical and mechanical mappings of the myocardium before and after the therapy, and anatomopathological examination of the myocardium of one of the patients that had deceased of a stroke eleven months after the treatment indicated sustained neoangiogenesis and improvement of activity and quantity of cardiomyocytes in the injected regions. Post-hoc analyses of injected cell phenotype and improvement of myocardial function indicate that presence of CD8+ and CD56+ cells does not correlate with good prognostics, suggesting a possibility of cell selection. For 'no-option' severe cardiac patients, significant benefits of cell therapy and absence of adverse effects may justify the application of bone-marrow-derived cell therapy. We describe cell therapy for severe ischemic heart failure using transendocardial injection of autologous bone-marrow-derived mononuclear cells. The treated patients had significantly less heart failure and angina, sustained significant improvement of pumping power, exercise capacity, cardiac muscle irrigation, and blood supply to the body. Electrical and mechanical mappings of the myocardium before and after the therapy, and anatomopathological examination of the myocardium of one of the patients that had deceased of a stroke eleven months after the treatment indicated sustained neoangiogenesis and improvement of activity and quantity of cardiomyocytes in the injected regions. Post-hoc analyses of injected cell phenotype and improvement of myocardial function indicate that presence of CD8+ and CD56+ cells does not correlate with good prognostics, suggesting a possibility of cell selection. For 'no-option' severe cardiac patients, significant benefits of cell therapy and absence of adverse effects may justify the application of bone-marrow-derived cell therapy.Original Abstract: Nous decrivons la therapie d'ischemies graves du myocarde par injections trans-endocardiques de cellules autologues mononucleaires de la moelle osseuse. Les malades traites ont montre une diminution significative de l'angine et une amelioration permanente de l'activite cardiaque, de la capacite d'exercice physique, d'irrigation du myocarde et de la circulation systemique. L'analyse de l'activite electrique et contractile du myocarde avant et quatre mois apres la therapie, ainsi que l'analyse anatomopathologique du coeur d'un des malades decede onze mois apres la therapie a la suite d'un accident vasculaire cerebral, ont revele une angiogenese et une augmentation de l'activite et de la quantite de cardiomyocytes dans les regions traitees. L'analyse comparative des resultats du traitement et de la composition de cellules injectees a montre que la quantite de cellules CD8+ et CD56+ n'est pas associee au bon pronostic. Ce resultat peut indiquer une selection de cellules de la moelle osseuse devant etre injectees. du fait de l'absence d'effets indesirables et du caractere significativement benefique du traitement decrit, les therapies cellulaires peuvent des a present representer une proposition raisonnable pour les malades a qui ne peut etre offerte aucune autre therapie. |
Author | Takiya, Christina M. Borojevic, Radovan Dohmann, Hans Fernando R. Silva, Suzana A. Souza, André L.S. Rossi, Maria Isabel D. |
Author_xml | – sequence: 1 givenname: Hans Fernando R. surname: Dohmann fullname: Dohmann, Hans Fernando R. – sequence: 2 givenname: Suzana A. surname: Silva fullname: Silva, Suzana A. – sequence: 3 givenname: André L.S. surname: Souza fullname: Souza, André L.S. – sequence: 4 givenname: Maria Isabel D. surname: Rossi fullname: Rossi, Maria Isabel D. – sequence: 5 givenname: Christina M. surname: Takiya fullname: Takiya, Christina M. – sequence: 6 givenname: Radovan surname: Borojevic fullname: Borojevic, Radovan email: radovan@histo.ufrj.br |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18956754$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17631451$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkUlrHDEQhUVwiLf8gRxCX5Jbd6RWawNfEuMNDL7YZ6GRSoyGXiZS9wT_-9QwA77ZIHg6fO_Vo-qcnIzTCIR8Y7RhlMlfm8bnXWpaSlVDWYPyiZwxJXXNW65P8C85q6k07JScl7KhaDJCfCGnCHHWCXZGbv5gZj24nKd_1TDhhMX34HLloe-reQ3ZbV-rKVYFdpChSsWvYUi-WiM0V9GlfslwST5H1xf4etQL8nJ783x9Xz8-3T1c_36sfWfoXEceDI-toMKzoFfRQJSrjq6MotoxR00Q3klJQ8dUx5UOPOADLOuV8ygX5Ochd5unvwuU2Q5YCJu6EaalWEWl1qqlH4K8baXQkn0IMsNVx0SLYHsAfZ5KyRDtNifc26tl1O7PYTd2fw67P4elzKKg6fsxfVkNEN4sx_0j8OMIuOJdH7MbfSpvnDZCKtEhd3XgALe7S5Bt8QlGDyFl8LMNU3qvx3_ksqnb |
CitedBy_id | crossref_primary_10_1016_j_ijcard_2010_02_075 crossref_primary_10_1007_s12265_009_9123_8 crossref_primary_10_1016_j_yexcr_2009_09_016 |
Cites_doi | 10.1161/01.RES.0000046045.00846.B0 10.1016/j.ahj.2006.07.018 10.1161/01.RES.0000147315.71699.51 10.1161/CIRCULATIONAHA.104.499178 10.1016/S0140-6736(03)12111-3 10.1056/NEJMoa055706 10.1016/S0735-1097(03)00328-0 10.1016/j.amjcard.2005.09.132 10.1016/j.gde.2003.08.001 10.1073/pnas.0600635103 10.1161/CIRCULATIONAHA.105.546218 10.1056/NEJMoa051779 10.1093/eurheartj/ehi793 10.1016/S0140-6736(00)03617-5 10.1253/circj.70.1180 |
ContentType | Journal Article Conference Proceeding |
Copyright | 2007 Académie des sciences 2008 INIST-CNRS |
Copyright_xml | – notice: 2007 Académie des sciences – notice: 2008 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 H94 7U5 8FD L7M 7X8 |
DOI | 10.1016/j.crvi.2007.01.007 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts AIDS and Cancer Research Abstracts Solid State and Superconductivity Abstracts Technology Research Database Advanced Technologies Database with Aerospace MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Immunology Abstracts Technology Research Database Advanced Technologies Database with Aerospace Solid State and Superconductivity Abstracts MEDLINE - Academic |
DatabaseTitleList | MEDLINE AIDS and Cancer Research Abstracts Technology Research Database MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) Biology |
DocumentTitleAlternate | Thérapie cellulaire de lésions ischémiques graves du myocarde |
EISSN | 1768-3238 |
EndPage | 549 |
ExternalDocumentID | 10_1016_j_crvi_2007_01_007 17631451 18956754 S1631069107000467 |
Genre | Journal Article Review |
GroupedDBID | --- --K --M -~X .~1 0R~ 1B1 1RT 1~. 1~5 29F 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ AABNK AACTN AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABFNM ABGRD ABGSF ABMAC ABXDB ABYKQ ACDAQ ACGFS ACIUM ADBBV ADEZE ADMUD ADQTV ADUVX AEKER AENEX AEQOU AFFNX AFPKN AFTJW AGHFR AGUBO AGYEJ AI. AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ BLXMC CBWCG CS3 DOVZS DU5 EBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FIRID FNPLU G-Q GBLVA GROUPED_DOAJ HVGLF HZ~ IHE J1W L7B LN9 M41 MO0 NCXOZ O-L O9- OAUVE OK1 OZT P-8 P-9 PC. Q38 RIG ROL RPZ SDF SDG SDP SEM SES SEW SSZ T5K UHS VH1 ~G- ABMYL AKRWK IQODW 0SF AAHBH ADVLN CGR CUY CVF ECM EIF NPM AAYXX ACRPL ADNMO AEXTA CITATION 7T5 H94 7U5 8FD L7M 7X8 |
ID | FETCH-LOGICAL-c490t-f3d93f2505c1d8bf9ef6b40b9708a1a09d5ca660d4174378d3dd3de763c7ac763 |
IEDL.DBID | .~1 |
ISSN | 1631-0691 |
IngestDate | Fri Oct 25 08:23:34 EDT 2024 Wed Dec 04 15:21:42 EST 2024 Wed Dec 04 15:12:12 EST 2024 Fri Dec 06 02:21:35 EST 2024 Sat Sep 28 07:43:26 EDT 2024 Tue Mar 12 09:24:14 EDT 2024 Fri Feb 23 02:27:15 EST 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 |
Keywords | Heart failure Angiogenesis Thérapie cellulaire Cell therapy Ischemia Myocarde Angiogenèse Myocardium Bone marrow Crise cardiaque Ischémie Moelle osseuse Heart Zoology Cardiovascular disease Biology Crisis Regeneration Mononuclear cell Treatment Heart disease Agriculture Circulatory system Neovascularization Severe |
Language | English |
License | CC BY 4.0 https://www.elsevier.com/tdm/userlicense/1.0 |
LinkModel | DirectLink |
MeetingName | Thérapie cellulaire régénérative |
MergedId | FETCHMERGED-LOGICAL-c490t-f3d93f2505c1d8bf9ef6b40b9708a1a09d5ca660d4174378d3dd3de763c7ac763 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
OpenAccessLink | https://comptes-rendus.academie-sciences.fr/biologies/item/10.1016/j.crvi.2007.01.007.pdf |
PMID | 17631451 |
PQID | 19374152 |
PQPubID | 23462 |
PageCount | 7 |
ParticipantIDs | proquest_miscellaneous_70688720 proquest_miscellaneous_32265861 proquest_miscellaneous_19374152 crossref_primary_10_1016_j_crvi_2007_01_007 pubmed_primary_17631451 pascalfrancis_primary_18956754 elsevier_sciencedirect_doi_10_1016_j_crvi_2007_01_007 |
PublicationCentury | 2000 |
PublicationDate | 2007-06-01 |
PublicationDateYYYYMMDD | 2007-06-01 |
PublicationDate_xml | – month: 06 year: 2007 text: 2007-06-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Paris |
PublicationPlace_xml | – name: Paris – name: France |
PublicationTitle | Comptes rendus. Biologies |
PublicationTitleAlternate | C R Biol |
PublicationYear | 2007 |
Publisher | Elsevier SAS Elsevier |
Publisher_xml | – name: Elsevier SAS – name: Elsevier |
References | Brehm, Strauer (bib006) 2006; 3-S1 Lunde, Solheim, Aakhus, Arnesen, Abdelnoor, Egeland, Endresen, Ilebekk, Manqschau, Fjeld, Smith, Teraldsrud, Grogaard, Bjornerheim, Brekke, Muller, Hopp, Ragnarsson, Brinchmann, Forfang (bib005) 2006; 355 Silva, Perin, Dohmann, Borojevic, Silva, Sousa, Assad, Vaughn, Mesquita, Belém, Carvalho, Dohmann, Willerson (bib010) 2004; 31 Dohmann, Perin, Takiya, Silva, Silva, Sousa, Mesquita, Rossi, Pascarelli, Assis, Dutra, Assad, Castello-Branco, Drummond, Dohmann, Willerson, Borojevic (bib016) 2005; 112 Menasché, Hagege, Scorsin, Pouzet, Desnos, Duboc, Schwartz, Vilquin, Marolleau (bib003) 2001; 357 Beeres, Bax, Dibbets-Schneider, Stokkel, Fibbe, van der Wall, Schalij, Atsma (bib014) 2006; 152 Perin, Dohmann, Borojevic, Silva, Sousa, Silva, Mesquita, Belém, Vaughn, Rangel, Assad, Carvalho, Rossi, Dohmann, Willerson (bib009) 2004; 110-S1 Messina, De Angelis, Frati, Morrone, Chimenti, Fiordaliso, Salio, Battaglia, Latronico, Coletta, Vivarelli, Frati, Cossu, Giacomello (bib018) 2004; 95 Tse, Kwong, Chan, Lo, Ho, Lau (bib013) 2003; 361 Fuchs, Satler, Kornowski, Okubagzi, Weisz, Baffour, Waksman, Weissman, Cerqueira, Leon, Epstein (bib011) 2003; 41 Urbanek, Cesselli, Rota, Nascimbene, De Angelis, Hosoda, Bearzi, Boni, Bolli, Kajstura, Anversa, Leri (bib019) 2006; 103 Assmus, Honold, Schächinger, Britten, Fischer-Rosokat, Lehmann, Teupe, Pistorius, Martin, Abolmaali, Tonn, Dimmler, Zeiher (bib004) 2006; 355 Bartunek, Dimmeler, Drexler, Fernandez-Aviles, Galinanes, Janssens, Martin, Mathur, Menasché, Priori, Strauer, Tendera, Wijns, Zeiher (bib007) 2006 Orlic, Hill, Arai (bib001) 2002; 91 Murry, Field, Menasché (bib002) 2005; 112 Izawa, Kondo, Usui, Yamamoto, Shintani, Inden, Isobe, Unno, Kajiguchi, Kato, Noda, Okumura, Naoe, Takamatsu, Komori, Ueda, Murohara (bib015) 2006; 70 Perin, Dohmann, Borojevic, Silva, Sousa, Mesquita, Rossi, Carvalho, Dutra, Dohmann, Silva, Belém, Vivacqua, Rangel, Esporcatte, Geng, Vaughn, Assad, Mesquita, Willerson (bib008) 2003; 120 Fuchs, Kornowski, Weisz, Satler, Smits, Okubagzi, Baffour, Aggarwal, Weissman, Cerqueira, Waksman, Serrruys, Battler, Moses, Leon, Epstein (bib012) 2006; 97 Cossu, Bianco (bib017) 2003; 13 Fuchs (10.1016/j.crvi.2007.01.007_bib012) 2006; 97 Izawa (10.1016/j.crvi.2007.01.007_bib015) 2006; 70 Messina (10.1016/j.crvi.2007.01.007_bib018) 2004; 95 Orlic (10.1016/j.crvi.2007.01.007_bib001) 2002; 91 Menasché (10.1016/j.crvi.2007.01.007_bib003) 2001; 357 Perin (10.1016/j.crvi.2007.01.007_bib008) 2003; 120 Urbanek (10.1016/j.crvi.2007.01.007_bib019) 2006; 103 Brehm (10.1016/j.crvi.2007.01.007_bib006) 2006; 3-S1 Silva (10.1016/j.crvi.2007.01.007_bib010) 2004; 31 Lunde (10.1016/j.crvi.2007.01.007_bib005) 2006; 355 Perin (10.1016/j.crvi.2007.01.007_bib009) 2004; 110-S1 Assmus (10.1016/j.crvi.2007.01.007_bib004) 2006; 355 Fuchs (10.1016/j.crvi.2007.01.007_bib011) 2003; 41 Cossu (10.1016/j.crvi.2007.01.007_bib017) 2003; 13 Bartunek (10.1016/j.crvi.2007.01.007_bib007) 2006 Dohmann (10.1016/j.crvi.2007.01.007_bib016) 2005; 112 Beeres (10.1016/j.crvi.2007.01.007_bib014) 2006; 152 Tse (10.1016/j.crvi.2007.01.007_bib013) 2003; 361 Murry (10.1016/j.crvi.2007.01.007_bib002) 2005; 112 |
References_xml | – volume: 31 start-page: 214 year: 2004 end-page: 219 ident: bib010 article-title: Catheter-based transendocardial delivery of autologous bone-marrow-derived mononuclear cells in patients listed for heart transplantation publication-title: Texas Heart Inst. J. contributor: fullname: Willerson – volume: 95 start-page: 911 year: 2004 end-page: 921 ident: bib018 article-title: Isolation and expansion of adult cardiac stem cells from human and murine heart publication-title: Circ. Res. contributor: fullname: Giacomello – volume: 70 start-page: 1180 year: 2006 end-page: 1183 ident: bib015 article-title: Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease publication-title: Circ. J. contributor: fullname: Murohara – volume: 13 start-page: 537 year: 2003 end-page: 542 ident: bib017 article-title: Mesoangioblasts – vascular progenitors for extravascular mesodermal tissues publication-title: Curr. Opin. Gen. Dev. contributor: fullname: Bianco – start-page: 1338 year: 2006 end-page: 1340 ident: bib007 article-title: The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart publication-title: Eur. Heart J. contributor: fullname: Zeiher – volume: 152 start-page: 11 year: 2006 end-page: 16 ident: bib014 article-title: Sustained effect of autologous bone marrow mononuclear cell injection in patients with refractory angina pectoris and chronic myocardial ischemia: Twelve-month follow-up results publication-title: Am. Heart J. contributor: fullname: Atsma – volume: 112 start-page: 521 year: 2005 end-page: 526 ident: bib016 article-title: Transendocardial autologous bone marrow mononuclear cell injection in ischemic heart failure: postmortem anatomopathological and immunohistochemical findings publication-title: Circulation contributor: fullname: Borojevic – volume: 355 start-page: 1189 year: 2006 end-page: 1191 ident: bib005 article-title: Inracoronary injection of mononuclear bone-marrow cells in acute myocardial infarction publication-title: N. Engl. J. Med. contributor: fullname: Forfang – volume: 97 start-page: 823 year: 2006 end-page: 829 ident: bib012 article-title: Safety and feasibility of transendocardial autologous bone-marrow cell transplantation in patients with advanced heart disease publication-title: Am. J. Cardiol. contributor: fullname: Epstein – volume: 91 start-page: 1092 year: 2002 end-page: 1102 ident: bib001 article-title: Stem cells for myocardial regeneration publication-title: Circ Res. contributor: fullname: Arai – volume: 355 start-page: 1222 year: 2006 end-page: 1232 ident: bib004 article-title: Transcoronary transplantation of progenitor cells after myocardial infarction publication-title: N. Engl. J. Med. contributor: fullname: Zeiher – volume: 361 start-page: 47 year: 2003 end-page: 49 ident: bib013 article-title: Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation publication-title: Lancet contributor: fullname: Lau – volume: 3-S1 start-page: 1001 year: 2006 end-page: 1004 ident: bib006 article-title: Stem cell therapy in postinfarction coronary heart disease publication-title: Nat. Clin. Pract. Cardiovasc. Med. contributor: fullname: Strauer – volume: 110-S1 start-page: 213 year: 2004 end-page: 218 ident: bib009 article-title: Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy publication-title: Circulation contributor: fullname: Willerson – volume: 357 start-page: 279 year: 2001 end-page: 280 ident: bib003 article-title: Myoblast transplantation for heart failure publication-title: Lancet contributor: fullname: Marolleau – volume: 112 start-page: 3174 year: 2005 end-page: 3183 ident: bib002 article-title: Cell-based cardiac repair. Reflections at the 10-year point publication-title: Circulation contributor: fullname: Menasché – volume: 103 start-page: 9226 year: 2006 end-page: 9231 ident: bib019 article-title: Stem cell niches in the adult mouse heart publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Leri – volume: 41 start-page: 1721 year: 2003 end-page: 1724 ident: bib011 article-title: Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study publication-title: J. Am. Coll. Cardiol. contributor: fullname: Epstein – volume: 120 start-page: 429 year: 2003 end-page: 440 ident: bib008 article-title: Transendocardial autologous bone-marrow cell transplant in severe, chronic ischemic heart failure publication-title: Circulation contributor: fullname: Willerson – volume: 91 start-page: 1092 year: 2002 ident: 10.1016/j.crvi.2007.01.007_bib001 article-title: Stem cells for myocardial regeneration publication-title: Circ Res. doi: 10.1161/01.RES.0000046045.00846.B0 contributor: fullname: Orlic – volume: 152 start-page: 11 year: 2006 ident: 10.1016/j.crvi.2007.01.007_bib014 article-title: Sustained effect of autologous bone marrow mononuclear cell injection in patients with refractory angina pectoris and chronic myocardial ischemia: Twelve-month follow-up results publication-title: Am. Heart J. doi: 10.1016/j.ahj.2006.07.018 contributor: fullname: Beeres – volume: 95 start-page: 911 year: 2004 ident: 10.1016/j.crvi.2007.01.007_bib018 article-title: Isolation and expansion of adult cardiac stem cells from human and murine heart publication-title: Circ. Res. doi: 10.1161/01.RES.0000147315.71699.51 contributor: fullname: Messina – volume: 120 start-page: 429 year: 2003 ident: 10.1016/j.crvi.2007.01.007_bib008 article-title: Transendocardial autologous bone-marrow cell transplant in severe, chronic ischemic heart failure publication-title: Circulation contributor: fullname: Perin – volume: 112 start-page: 521 year: 2005 ident: 10.1016/j.crvi.2007.01.007_bib016 article-title: Transendocardial autologous bone marrow mononuclear cell injection in ischemic heart failure: postmortem anatomopathological and immunohistochemical findings publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.104.499178 contributor: fullname: Dohmann – volume: 3-S1 start-page: 1001 year: 2006 ident: 10.1016/j.crvi.2007.01.007_bib006 article-title: Stem cell therapy in postinfarction coronary heart disease publication-title: Nat. Clin. Pract. Cardiovasc. Med. contributor: fullname: Brehm – volume: 361 start-page: 47 year: 2003 ident: 10.1016/j.crvi.2007.01.007_bib013 article-title: Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation publication-title: Lancet doi: 10.1016/S0140-6736(03)12111-3 contributor: fullname: Tse – volume: 110-S1 start-page: 213 year: 2004 ident: 10.1016/j.crvi.2007.01.007_bib009 article-title: Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy publication-title: Circulation contributor: fullname: Perin – volume: 355 start-page: 1189 year: 2006 ident: 10.1016/j.crvi.2007.01.007_bib005 article-title: Inracoronary injection of mononuclear bone-marrow cells in acute myocardial infarction publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa055706 contributor: fullname: Lunde – volume: 41 start-page: 1721 year: 2003 ident: 10.1016/j.crvi.2007.01.007_bib011 article-title: Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(03)00328-0 contributor: fullname: Fuchs – volume: 97 start-page: 823 year: 2006 ident: 10.1016/j.crvi.2007.01.007_bib012 article-title: Safety and feasibility of transendocardial autologous bone-marrow cell transplantation in patients with advanced heart disease publication-title: Am. J. Cardiol. doi: 10.1016/j.amjcard.2005.09.132 contributor: fullname: Fuchs – volume: 31 start-page: 214 year: 2004 ident: 10.1016/j.crvi.2007.01.007_bib010 article-title: Catheter-based transendocardial delivery of autologous bone-marrow-derived mononuclear cells in patients listed for heart transplantation publication-title: Texas Heart Inst. J. contributor: fullname: Silva – volume: 13 start-page: 537 year: 2003 ident: 10.1016/j.crvi.2007.01.007_bib017 article-title: Mesoangioblasts – vascular progenitors for extravascular mesodermal tissues publication-title: Curr. Opin. Gen. Dev. doi: 10.1016/j.gde.2003.08.001 contributor: fullname: Cossu – volume: 103 start-page: 9226 year: 2006 ident: 10.1016/j.crvi.2007.01.007_bib019 article-title: Stem cell niches in the adult mouse heart publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0600635103 contributor: fullname: Urbanek – volume: 112 start-page: 3174 year: 2005 ident: 10.1016/j.crvi.2007.01.007_bib002 article-title: Cell-based cardiac repair. Reflections at the 10-year point publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.546218 contributor: fullname: Murry – volume: 355 start-page: 1222 year: 2006 ident: 10.1016/j.crvi.2007.01.007_bib004 article-title: Transcoronary transplantation of progenitor cells after myocardial infarction publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa051779 contributor: fullname: Assmus – start-page: 1338 year: 2006 ident: 10.1016/j.crvi.2007.01.007_bib007 article-title: The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehi793 contributor: fullname: Bartunek – volume: 357 start-page: 279 year: 2001 ident: 10.1016/j.crvi.2007.01.007_bib003 article-title: Myoblast transplantation for heart failure publication-title: Lancet doi: 10.1016/S0140-6736(00)03617-5 contributor: fullname: Menasché – volume: 70 start-page: 1180 year: 2006 ident: 10.1016/j.crvi.2007.01.007_bib015 article-title: Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease publication-title: Circ. J. doi: 10.1253/circj.70.1180 contributor: fullname: Izawa |
SSID | ssj0016955 |
Score | 1.8513165 |
SecondaryResourceType | review_article |
Snippet | We describe cell therapy for severe ischemic heart failure using transendocardial injection of autologous bone-marrow-derived mononuclear cells. The treated... |
SourceID | proquest crossref pubmed pascalfrancis elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 543 |
SubjectTerms | Agronomy. Soil science and plant productions Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Angiogenèse Animals Applied cell therapy and gene therapy Biological and medical sciences Bone marrow Bone Marrow Transplantation Cell therapy Crise cardiaque Electrophysiology Fundamental and applied biological sciences. Psychology General aspects Heart failure Humans Ischemia Ischémie Medical sciences Moelle osseuse Myocarde Myocardial Ischemia - therapy Myocardium Myocytes, Cardiac - transplantation Thérapie cellulaire Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
Title | Bone-marrow mononuclear cell therapy of severe ischemic heart failure |
URI | https://dx.doi.org/10.1016/j.crvi.2007.01.007 https://www.ncbi.nlm.nih.gov/pubmed/17631451 https://search.proquest.com/docview/19374152 https://search.proquest.com/docview/32265861 https://search.proquest.com/docview/70688720 |
Volume | 330 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NS-tAEB-kIAgP8etp_ah7eAdFYjftfiRHFUUE3-U9wduy2Q-oYFvaevDi3-5MslE81IMQ2BAmZDO7M_vbZGZ-AH9KKZRyNmQDNJ5MyCHanB_4TAft8cS5MtIf3fu_6vZB3D3KxxW4anNhKKwy-f7Gp9feOl3pJ232p6NR_x8iCdzP4HKn6xRIyigXkhOLwfnbR5hHrsqa-ZSEM5JOiTNNjJdDc0xlDHMqor1scfo1tXNUWWy4LpaD0XpRutmA9YQm2UXT4U1YCeMtWG34JV-3YDNZ7pydpPLSp9twfTkZh-y5Lr7IcBJOxlTS2M4YfcNnTT7WK5tEht0Ks8BGuP-lCHpG3NcLFu2IItl34OHm-v_VbZbIFDInSr7I4tCXw0iAx-W-qGIZoqoEr0rNC5tbXnrprFLcC9qj6MIPPR4B3Y_T1mHzGzrYo7AHTHLPVYHXKstFJQNCCmVJNOaVVip24azVopk2NTNMG0z2ZEjnRH6pDc8NNl2QraLNl5E36NS_va_3ZVQ-H1Xgnk9L0YXjdpgM2gwp0Y7D5GVuELQSkBosl0A3h9BM5cslNLH16AHvwm4zAz6fj8oi_uP9H77YAay1QYk8P4TOYvYSjhD5LKpePbXfAT7xALw |
link.rule.ids | 309,310,314,780,784,789,790,4502,23930,23931,25140,27924,27925,45585 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB5RqgqkCpVHYQsFH3oAobDOrh_JERBo2wIXQOJmOX5IW4nd1e5y4NLf3pnEAXFYDpUiObImsjP2jL9J5gHwo5RCKWdD1kPhyYTso8z5ns900B5vnCsj_dG9vlGDe_HrQT4swXkbC0NulUn3Nzq91tapp5u42Z0Mh91bRBJoz-Bxp-sQSP0BPgqJ6Bc39cnfFz-PXJV16VOizog8Rc40Tl4O5THlMcwpi_ai0-nzxM6QZ7EpdrEYjdan0uUXWEtwkp02M16HpTDagE9NgcnnDVhPojtjhym_9NEmXJyNRyF7rLMvMtyF4xHlNLZTRh_xWROQ9czGkeG0wjSwIRrA5ELPqPj1nEU7JFf2Lbi_vLg7H2SpmkLmRMnnWez7sh8J8bjcF1UsQ1SV4FWpeWFzy0svnVWKe0FGii583-MVUP84bR02X2EZZxR2gEnuuSqwr7JcVDIgplCWSGNeaaViB45bLppJkzTDtN5kfwzxnKpfasNzg00HZMto82bpDWr1d5_bf7Mqr0MVaPRpKTpw0C6TQaEhJtpRGD_NDKJWQlK9xRSo5xCbqXwxhaZyPbrHO7Dd7IDX8ZFZVAD523--2AGsDO6ur8zVz5vfu7DaeijyfA-W59On8B1h0Lzar7f5P0t7A-c |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=proceeding&rft.title=Comptes+rendus.+Biologies&rft.atitle=Bone-marrow+mononuclear+cell+therapy+of+severe+ischemic+heart+failure&rft.au=DOHMANN%2C+Hans+Fernando+R&rft.au=SILVA%2C+Suzana+A&rft.au=SOUZA%2C+Andr%C3%A9+L.+S&rft.au=ROSSI%2C+Maria+Isabel+D&rft.date=2007-06-01&rft.pub=Elsevier&rft.issn=1631-0691&rft.eissn=1768-3238&rft.volume=330&rft.issue=6-7&rft.spage=543&rft.epage=549&rft_id=info:doi/10.1016%2Fj.crvi.2007.01.007&rft.externalDBID=n%2Fa&rft.externalDocID=18956754 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1631-0691&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1631-0691&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1631-0691&client=summon |