Citroflavonoids as Promising Agents for Drug Discovery in Diabetes and Hypertension: A Systematic Review of Experimental Studies

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 22; p. 7933
• Main Authors: Ortiz-Andrade, Rolffy, Araujo León, Jesús Alfredo, Sánchez-Salgado, Juan Carlos, Sánchez-Recillas, Amanda, Vazquez-Garcia, Priscila, Hernández-Núñez, Emanuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.11.2022; MDPI
• Subjects: biochemical parameters; Biological activity; Biomarkers; blood markers; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Citrus; Citrus fruits; Diabetes; Diabetes mellitus; Diabetes Mellitus - drug therapy; Diabetes therapy; Diet; Drug approval; Drug development; Drug Discovery; Drug dosages; Drug therapy; Enzymes; Flavonoids; Flavonoids - pharmacology; Flavonoids - therapeutic use; Gene expression; Glucose; Heart rate; Hemorrhoids; Hesperidin; Heterogeneity; Hypertension; Hypertension - drug therapy; Insulin; Isoflavones; Lipids; Liver; Metabolism; Metabolites; Naringenin; protein content; Proteins; Systematic Review; naringenin; blood markers; biochemical parameters; protein content; gene expression; hesperidin
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27227933

Flavonoids are naturally occurring compounds widely distributed in the genus. These natural compounds have many health benefits, mainly for metabolic and cardiovascular diseases. In fact, some these compounds are components of drug products with approved indications for peripheral vascular insufficiency and hemorrhoids. However, information on pharmacological effects of these compounds remains disperse and there is scarce comprehensive analysis of whole data and evidence. These kinds of evidence analyses could be necessary in drug design and the development of novel and innovate drug products in diabetes and hypertension. We aimed to systematically search for evidence on the efficacy of citroflavonoids in diabetes and hypertension in in vivo models. We searched four literature databases based on a PICO strategy. After database curation, twenty-nine articles were retrieved to analyze experimental data. There was high heterogeneity in both outcomes and methodology. Naringenin and hesperetin derivates were the most studied citroflavonoids in both experimental models. More investigation is still needed to determine its potential for drug design and development.