In vitro drug release mechanism and drug loading studies of cubic phase gels

• Published in: International journal of pharmaceutics Vol. 293; no. 1; pp. 241 - 250
• Main Authors: Lara, Marilisa G., Bentley, M. Vitória L.B., Collett, John H.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 11.04.2005; Elsevier
• Subjects: Biological and medical sciences; Cubic phase; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug delivery systems; Gels - chemistry; Gels - pharmacokinetics; General pharmacology; Glyceryl monooleate; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Swelling studies; Drug delivery systems; Swelling studies; Glyceryl monooleate; Cubic phase; Drug; Delivery system; Pharmaceutical technology; Swelling; In vitro; Colloidal gel; Dosage form; Mechanism of action; Release
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2005.01.008

Glyceryl monooleate/water cubic phase systems were investigated as drug delivery systems, using salicylic acid as a model drug. The liquid crystalline phases formed by the glyceryl monooleate (GMO)/water systems were characterized by polarizing microscopy. In vitro drug release studies were performed and the influences of initial water content, swelling and drug loading on the drug release properties were evaluated. Water uptake followed second-order swelling kinetics. In vitro release profiles showed Fickian diffusion control and were independent on the initial water content and drug loading, suggesting GMO cubic phase gels suitability for use as drug delivery system.