Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects

• Published in: Fertility and sterility Vol. 108; no. 6; pp. 993 - 998
• Main Authors: Woo, Irene, Hindoyan, Rita, Landay, Melanie, Ho, Jacqueline, Ingles, Sue Ann, McGinnis, Lynda K., Paulson, Richard J., Chung, Karine
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2017
• Subjects: Adult; Assisted reproductive technology; Birth Weight; embryo culture; Embryo Transfer - adverse effects; Female; Fertility; Fertilization in Vitro - adverse effects; Gestational Age; gestational carrier; gestational surrogacy; Humans; Infant, Newborn; in vitro fertilization; Live Birth; perinatal outcome; Pregnancy; Pregnancy Complications - etiology; Pregnancy Rate; Retrospective Studies; Risk Factors; Surrogate Mothers; Treatment Outcome; gestational carrier; Assisted reproductive technology; in vitro fertilization; gestational surrogacy; perinatal outcome; embryo culture
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2017.09.014

To study the perinatal outcomes between singleton live births achieved with the use of commissioned versus spontaneously conceived embryos carried by the same gestational surrogate. Retrospective cohort study. Academic in vitro fertilization center. Gestational surrogate. None. Pregnancy outcome, gestational age at birth, birth weight, perinatal complications. We identified 124 gestational surrogates who achieved a total of 494 pregnancies. Pregnancy outcomes for surrogate and spontaneous pregnancies were significantly different (P<.001), with surrogate pregnancies more likely to result in twin pregnancies: 33% vs. 1%. Miscarriage and ectopic rates were similar. Of these pregnancies, there were 352 singleton live births: 103 achieved from commissioned embryos and 249 conceived spontaneously. Surrogate births had lower mean gestational age at delivery (38.8 ± 2.1 vs. 39.7 ± 1.4), higher rates of preterm birth (10.7% vs. 3.1%), and higher rates of low birth weight (7.8% vs. 2.4%). Neonates from surrogacy had birth weights that were, on average, 105 g lower. Surrogate births had significantly higher obstetrical complications, including gestational diabetes, hypertension, use of amniocentesis, placenta previa, antibiotic requirement during labor, and cesarean section. Neonates born from commissioned embryos and carried by gestational surrogates have increased adverse perinatal outcomes, including preterm birth, low birth weight, hypertension, maternal gestational diabetes, and placenta previa, compared with singletons conceived spontaneously and carried by the same woman. Our data suggest that assisted reproductive procedures may potentially affect embryo quality and that its negative impact can not be overcome even with a proven healthy uterine environment.