Functional Integration Between the Two Brain Hemispheres: Evidence From the Homotopic Functional Connectivity Under Resting State

Functional integration among neural units is one of the fundamental principles in brain organization that could be examined using resting-state functional connectivity (rs-FC). Interhemispheric functional integration plays a critical role in human cognition. Homotopic functional connectivity (HoFC)...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neuroscience Vol. 14; p. 932
Main Authors Jin, Xinhu, Liang, Xinyu, Gong, Gaolang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 02.10.2020
Frontiers Media S.A
Subjects
Brain
Brain architecture
Brain mapping
Cerebral hemispheres
Cognition & reasoning
Cognitive ability
functional integration
Functional magnetic resonance imaging
Functional morphology
Hemispheric laterality
homotopic functional connectivity
Information processing
Integration
Investigations
left and right brain hemispheres
Medical imaging
Neural networks
Neuroimaging
Neuroscience
Neurosciences
resting-state functional connectivity
resting-state functional magnetic resonance imaging
Time series
resting-state functional magnetic resonance imaging
resting-state functional connectivity
homotopic functional connectivity
functional integration
left and right brain hemispheres
Online AccessGet full text

Cover

Abstract Functional integration among neural units is one of the fundamental principles in brain organization that could be examined using resting-state functional connectivity (rs-FC). Interhemispheric functional integration plays a critical role in human cognition. Homotopic functional connectivity (HoFC) under resting state provide an avenue to investigate functional integration between the two brain hemispheres, which can improve the present understanding of how interhemispheric interactions affect cognitive processing. In this review, we summarize the progress of HoFC studies under resting state and highlight how these findings have enhanced our understanding of interhemispheric functional organization of the human brain. Future studies are encouraged to address particular methodological issues and to further ascertain behavioral correlates, brain disease's modulation, task influence, and genetic basis of HoFC.
AbstractList Functional integration among neural units is one of the fundamental principles in brain organization that could be examined using resting-state functional connectivity (rs-FC). Interhemispheric functional integration plays a critical role in human cognition. Homotopic functional connectivity (HoFC) under resting state provide an avenue to investigate functional integration between the two brain hemispheres, which can improve the present understanding of how interhemispheric interactions affect cognitive processing. In this review, we summarize the progress of HoFC studies under resting state and highlight how these findings have enhanced our understanding of interhemispheric functional organization of the human brain. Future studies are encouraged to address particular methodological issues and to further ascertain behavioral correlates, brain disease’s modulation, task influence, and genetic basis of HoFC.
Functional integration among neural units is one of the fundamental principles in brain organization that can be examined using resting-state functional connectivity (rs-FC). From a left- and right-hemisphere perspective, previous studies have reported that interhemispheric functional integration plays a critical role in cognition. Homotopic functional connectivity (HoFC) under resting state can allow the direct investigation of functional integration between the two brain hemispheres and improve the present understanding of how interhemispheric interactions affect cognitive processing. In this review, we summarize the progress of HoFC studies performed with resting-state functional magnetic resonance imaging (rs-fMRI) and emphasize how these findings have enhanced our understanding of hemispheric functional organization in the human brain. Future approaches are encouraged to address particular methodological issues and to further identify the behavioral correlation, disease's modulation, task influence and genetic basis of HoFC.
Functional integration among neural units is one of the fundamental principles in brain organization that could be examined using resting-state functional connectivity (rs-FC). Interhemispheric functional integration plays a critical role in human cognition. Homotopic functional connectivity (HoFC) under resting state provide an avenue to investigate functional integration between the two brain hemispheres, which can improve the present understanding of how interhemispheric interactions affect cognitive processing. In this review, we summarize the progress of HoFC studies under resting state and highlight how these findings have enhanced our understanding of interhemispheric functional organization of the human brain. Future studies are encouraged to address particular methodological issues and to further ascertain behavioral correlates, brain disease's modulation, task influence, and genetic basis of HoFC.Functional integration among neural units is one of the fundamental principles in brain organization that could be examined using resting-state functional connectivity (rs-FC). Interhemispheric functional integration plays a critical role in human cognition. Homotopic functional connectivity (HoFC) under resting state provide an avenue to investigate functional integration between the two brain hemispheres, which can improve the present understanding of how interhemispheric interactions affect cognitive processing. In this review, we summarize the progress of HoFC studies under resting state and highlight how these findings have enhanced our understanding of interhemispheric functional organization of the human brain. Future studies are encouraged to address particular methodological issues and to further ascertain behavioral correlates, brain disease's modulation, task influence, and genetic basis of HoFC.
Author Gong, Gaolang
Liang, Xinyu
Jin, Xinhu
AuthorAffiliation 1 State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University , Beijing , China
2 Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University , Beijing , China
AuthorAffiliation_xml – name: 1 State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University , Beijing , China
– name: 2 Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University , Beijing , China
Author_xml – sequence: 1
  givenname: Xinhu
  surname: Jin
  fullname: Jin, Xinhu
– sequence: 2
  givenname: Xinyu
  surname: Liang
  fullname: Liang, Xinyu
– sequence: 3
  givenname: Gaolang
  surname: Gong
  fullname: Gong, Gaolang
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33122984$$D View this record in MEDLINE/PubMed
BookMark eNp1kk1vEzEQhleoiH7AnROyxIVLwqy_suaARKOWRKqEBEHiZjn2bOJoYwev06pH_jlOUqq0Eid7xs-8Gs-859VJiAGr6m0NQ8Ya9bENPvRDChSGAIrRF9VZLSUdcMF-nRzdT6vzvl8BSNpw-qo6ZaymVDX8rPpzvQ02-xhMR6Yh4yKZXUQuMd8hBpKXSGZ3kVwm4wOZ4Nr3myUm7D-Rq1vvMFgk1ymu9-AkrmOOG2_Jkeo4hoAluPX5nvwMDhP5jn32YUF-ZJPxdfWyNV2Pbx7Oi2p2fTUbTwY3375Ox19uBpYryAMcUeeMGklkLa1rq-aKOkEBuGNgqAEqqLDWoeHOinrUWoEGHMwtF6CQXVTTg6yLZqU3ya9NutfReL1PxLTQJmVvO9SMtkIJ1aCTlmMLSjE3aiSzjXJArStanw9am-18jc5iyMl0T0SfvgS_1It4q0dCylo2ReDDg0CKv7dlGrrM1WLXmYBx22vKheQ1cJAFff8MXcVtKoPdUbyBskYpCvXuuKPHVv4tugBwAGyKfZ-wfURq0Dsv6b2X9M5Leu-lUiKflVif9-4of_Ld_wv_AhG50b0
CitedBy_id crossref_primary_10_1093_cercor_bhac131
crossref_primary_10_1093_cercor_bhac130
crossref_primary_10_1007_s00221_022_06346_2
crossref_primary_10_1162_imag_a_00205
crossref_primary_10_1007_s00429_021_02312_w
crossref_primary_10_1007_s00429_022_02572_0
crossref_primary_10_1016_j_ijpsycho_2024_112460
crossref_primary_10_1016_j_jad_2024_08_023
crossref_primary_10_1016_j_heliyon_2024_e30347
crossref_primary_10_1360_TB_2023_1284
crossref_primary_10_3389_fneur_2022_852330
crossref_primary_10_1093_psyrad_kkac016
crossref_primary_10_1016_j_brainres_2024_148831
crossref_primary_10_1080_14737175_2023_2221788
crossref_primary_10_1016_j_neuroimage_2021_118368
crossref_primary_10_1016_j_bja_2021_08_033
crossref_primary_10_3389_fnagi_2022_862107
crossref_primary_10_1007_s11682_023_00814_1
crossref_primary_10_1016_j_bbr_2021_113383
crossref_primary_10_1371_journal_pone_0259051
Cites_doi 10.1371/journal.pone.0113181
10.1016/j.neuron.2014.05.014
10.3389/fnagi.2018.00161
10.3389/fnagi.2020.00020
10.1038/nrn2201
10.1007/s11065-005-6252-y
10.1002/ana.410180210
10.1016/j.neuroimage.2018.03.051
10.1371/journal.pone.0048847
10.1073/pnas.0811168106
10.1523/JNEUROSCI.3980-15.2016
10.1016/j.pnpbp.2012.11.003
10.1016/j.neuroimage.2019.116065
10.1038/s41593-019-0379-2
10.1523/JNEUROSCI.4544-08.2008
10.1006/nimg.2001.0978
10.1523/JNEUROSCI.2128-13.2013
10.1073/pnas.0909969107
10.1016/j.neuroimage.2010.05.073
10.1016/j.jns.2015.02.046
10.1093/cercor/bhi016
10.1016/0028-3932(95)00018-X
10.1007/s11682-020-00266-x
10.1002/hbm.23097
10.1016/0028-3932(90)90032-J
10.1016/B978-012264841-0/50050-0
10.1073/pnas.1302581110
10.1523/JNEUROSCI.2612-10.2010
10.1007/s11682-017-9794-8
10.1002/mrm.1910340409
10.1016/j.siny.2006.07.001
10.1073/pnas.91.11.5033
10.1002/hbm.23214
10.1007/s00429-015-1068-x
10.1073/pnas.1707050114
10.1371/journal.pone.0099980
10.1038/jcbfm.1984.73
10.1006/nimg.1997.0315
10.1016/j.jad.2018.07.037
10.1002/hbm.23502
10.1016/j.biopsych.2010.11.022
10.1016/j.jneumeth.2015.07.013
10.1016/j.nicl.2020.102175
10.1016/j.bandl.2017.12.002
10.1093/cercor/bhq035
10.1371/journal.pone.0071275
10.1523/JNEUROSCI.0573-08.2008
10.1016/j.eplepsyres.2014.06.010
10.1016/j.dcn.2013.11.004
10.1073/pnas.1700765114
10.1523/jneurosci.09-02-00600.1989
10.1155/2015/692684
10.1016/j.schres.2012.07.027
10.1016/0197-4580(96)00007-3
10.1073/pnas.1503436112
10.1093/cercor/bhr230
10.1089/brain.2013.0175
ContentType Journal Article
Copyright Copyright © 2020 Jin, Liang and Gong.
2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © 2020 Jin, Liang and Gong. 2020 Jin, Liang and Gong
Copyright_xml – notice: Copyright © 2020 Jin, Liang and Gong.
– notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright © 2020 Jin, Liang and Gong. 2020 Jin, Liang and Gong
DBID AAYXX
CITATION
NPM
3V.
7XB
88I
8FE
8FH
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M2P
M7P
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.3389/fnins.2020.00932
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
ProQuest Central (purchase pre-March 2016)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Journals
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
Biological Science Database
ProQuest SciTech Collection
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
PubMed
Publicly Available Content Database
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1662-453X
ExternalDocumentID oai_doaj_org_article_32f59598ed6c4ef0993d7863c89d02cd
PMC7566168
33122984
10_3389_fnins_2020_00932
Genre Journal Article
Review
GrantInformation_xml – fundername: Fundamental Research Funds for the Central Universities
GroupedDBID ---
29H
2WC
53G
5GY
5VS
88I
8FE
8FH
9T4
AAFWJ
AAYXX
ABUWG
ACGFO
ACGFS
ACXDI
ADRAZ
AEGXH
AENEX
AFKRA
AFPKN
AIAGR
ALMA_UNASSIGNED_HOLDINGS
AZQEC
BBNVY
BENPR
BHPHI
BPHCQ
CCPQU
CITATION
CS3
DIK
DU5
DWQXO
E3Z
EBS
EJD
EMOBN
F5P
FRP
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HYE
KQ8
LK8
M2P
M48
M7P
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
RNS
RPM
W2D
C1A
NPM
PQGLB
3V.
7XB
8FK
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c490t-e72dda976e3f211c9b92d52004d30a2a02525ccdea4dc517fc5ea0d0bc4509e3
IEDL.DBID DOA
ISSN 1662-453X
1662-4548
IngestDate Wed Aug 27 01:17:07 EDT 2025
Thu Aug 21 18:26:04 EDT 2025
Fri Jul 11 12:36:47 EDT 2025
Fri Jul 25 11:53:25 EDT 2025
Mon Jul 21 06:04:12 EDT 2025
Tue Jul 01 01:39:14 EDT 2025
Thu Apr 24 22:58:39 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords resting-state functional magnetic resonance imaging
resting-state functional connectivity
homotopic functional connectivity
functional integration
left and right brain hemispheres
Language English
License Copyright © 2020 Jin, Liang and Gong.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c490t-e72dda976e3f211c9b92d52004d30a2a02525ccdea4dc517fc5ea0d0bc4509e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience
Edited by: Xin Di, New Jersey Institute of Technology, United States
These authors have contributed equally to this work
Reviewed by: Dapeng Liu, Johns Hopkins University, United States; Ye He, Indiana University, United States; Zhengjia Dai, Sun Yat-sen University, China
OpenAccessLink https://doaj.org/article/32f59598ed6c4ef0993d7863c89d02cd
PMID 33122984
PQID 2448029865
PQPubID 4424402
ParticipantIDs doaj_primary_oai_doaj_org_article_32f59598ed6c4ef0993d7863c89d02cd
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7566168
proquest_miscellaneous_2456410406
proquest_journals_2448029865
pubmed_primary_33122984
crossref_primary_10_3389_fnins_2020_00932
crossref_citationtrail_10_3389_fnins_2020_00932
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-10-02
PublicationDateYYYYMMDD 2020-10-02
PublicationDate_xml – month: 10
  year: 2020
  text: 2020-10-02
  day: 02
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Lausanne
PublicationTitle Frontiers in neuroscience
PublicationTitleAlternate Front Neurosci
PublicationYear 2020
Publisher Frontiers Research Foundation
Frontiers Media S.A
Publisher_xml – name: Frontiers Research Foundation
– name: Frontiers Media S.A
References Ye (B58) 2020; 25
Biswal (B1) 1995; 34
Fan (B10) 2018; 240
Johnston (B28) 2008; 28
Bloom (B2) 2005; 15
Kelly (B31) 2011; 69
Tomasi (B49) 2012; 22
Cao (B3) 2014; 7
Joliot (B29) 2015; 254
Nielsen (B38) 2013; 8
Galaburda (B13) 1990; 28
Chen (B5) 2019; 202
Hoptman (B24) 2012; 141
Fox (B11) 2007; 8
Chen (B4) 2020
van den Heuvel (B53) 2013; 33
Lezak (B33) 2004
Shen (B45) 2015; 112
Smyser (B46) 2010; 20
Emerson (B9) 2016; 36
Luo (B36) 2018; 10
Woldehawariat (B55) 2014; 9
Tobyne (B48) 2016; 37
Galaburda (B14) 1985; 18
Gee (B16) 2011; 54
Tzourio-Mazoyer (B51) 2016; 221
Gracia-Tabuenca (B19) 2018; 174
Yazgan (B57) 1995; 33
Innocenti (B26) 1986; 9
Honey (B23) 2009; 106
Kanchibhotla (B30) 2014; 9
Cole (B6) 2014; 83
Tononi (B50) 1994; 91
Hermesdorf (B22) 2016; 37
Ren (B42) 2015; 351
Luo (B35) 2015; 2015
Zhao (B59) 2020; 12
Mollink (B37) 2019; 22
Duffy (B8) 1996; 17
Ge (B15) 2017; 114
Guo (B20) 2018; 12
Lowe (B34) 1998; 7
Roland (B43) 2017; 114
Gotts (B18) 2013; 110
Guo (B21) 2013; 41
Nuttall (B39) 2018; 187
Kostović (B32) 2006; 11
Vuoksimaa (B54) 2017; 38
Glahn (B17) 2010; 107
Zuo (B60) 2010; 30
Jo (B27) 2012; 7
Yang (B56) 2014; 108
Cordes (B7) 2000; 21
Horwitz (B25) 1984; 4
Salvador (B44) 2005; 15
Tzourio-Mazoyer (B52) 2002; 15
Quigley (B41) 2003; 24
Stark (B47) 2008; 28
Friston (B12) 2004
Owen (B40) 2013; 3
References_xml – volume: 9
  year: 2014
  ident: B30
  article-title: Genetics of microstructure of the corpus callosum in older adults.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0113181
– volume: 83
  start-page: 238
  year: 2014
  ident: B6
  article-title: Intrinsic and task-evoked network architectures of the human brain.
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.05.014
– volume: 10
  year: 2018
  ident: B36
  article-title: Decreased bilateral FDG-PET uptake and inter-hemispheric connectivity in multi-domain amnestic mild cognitive impairment patients: a preliminary study.
  publication-title: Front. Aging Neurosci.
  doi: 10.3389/fnagi.2018.00161
– volume: 12
  year: 2020
  ident: B59
  article-title: Age-related decreases in interhemispheric resting-state functional connectivity and their relationship with executive function.
  publication-title: Front. Aging Neurosci
  doi: 10.3389/fnagi.2020.00020
– year: 2004
  ident: B33
  publication-title: Neuropsychological Assessment.
– volume: 8
  start-page: 700
  year: 2007
  ident: B11
  article-title: Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2201
– volume: 15
  start-page: 59
  year: 2005
  ident: B2
  article-title: The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition?
  publication-title: Neuropsychol. Rev.
  doi: 10.1007/s11065-005-6252-y
– volume: 18
  start-page: 222
  year: 1985
  ident: B14
  article-title: Developmental dyslexia: four consecutive patients with cortical anomalies.
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.410180210
– volume: 174
  start-page: 441
  year: 2018
  ident: B19
  article-title: Hemispheric asymmetry and homotopy of resting state functional connectivity correlate with visuospatial abilities in school-age children.
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2018.03.051
– volume: 7
  year: 2012
  ident: B27
  article-title: Quantifying agreement between anatomical and functional interhemispheric correspondences in the resting brain.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0048847
– volume: 106
  start-page: 2035
  year: 2009
  ident: B23
  article-title: Predicting human resting-state functional connectivity from structural connectivity.
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.0811168106
– volume: 36
  start-page: 10883
  year: 2016
  ident: B9
  article-title: Longitudinal study of the emerging functional connectivity asymmetry of primary language regions during infancy.
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3980-15.2016
– volume: 41
  start-page: 24
  year: 2013
  ident: B21
  article-title: Decreased interhemispheric resting-state functional connectivity in first-episode, drug-naive major depressive disorder.
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2012.11.003
– volume: 202
  year: 2019
  ident: B5
  article-title: Brain hemispheric involvement in visuospatial and verbal divergent thinking.
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2019.116065
– volume: 22
  start-page: 809
  year: 2019
  ident: B37
  article-title: The spatial correspondence and genetic influence of interhemispheric connectivity with white matter microstructure.
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-019-0379-2
– volume: 24
  start-page: 208
  year: 2003
  ident: B41
  article-title: Role of the corpus callosum in functional connectivity.
  publication-title: AJNR Am. J. Neuroradiol.
– volume: 28
  start-page: 13754
  year: 2008
  ident: B47
  article-title: Regional variation in interhemispheric coordination of intrinsic hemodynamic fluctuations.
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4544-08.2008
– volume: 15
  start-page: 273
  year: 2002
  ident: B52
  article-title: Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.
  publication-title: Neuroimage
  doi: 10.1006/nimg.2001.0978
– volume: 33
  start-page: 14489
  year: 2013
  ident: B53
  article-title: An anatomical substrate for integration among functional networks in human cortex.
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2128-13.2013
– volume: 107
  start-page: 1223
  year: 2010
  ident: B17
  article-title: Genetic control over the resting brain.
  publication-title: Proc. Natl. Acad. Sci.U.S.A.
  doi: 10.1073/pnas.0909969107
– volume: 54
  start-page: 517
  year: 2011
  ident: B16
  article-title: Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres.
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2010.05.073
– volume: 351
  start-page: 93
  year: 2015
  ident: B42
  article-title: Increased interhemispheric resting-state functional connectivity in paroxysmal kinesigenic dyskinesia: a resting-state fMRI study.
  publication-title: J. Neurol. Sci.
  doi: 10.1016/j.jns.2015.02.046
– volume: 15
  start-page: 1332
  year: 2005
  ident: B44
  article-title: Neurophysiological architecture of functional magnetic resonance images of human brain.
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhi016
– volume: 33
  start-page: 769
  year: 1995
  ident: B57
  article-title: Functional significance of individual variations in callosal area.
  publication-title: Neuropsychologia
  doi: 10.1016/0028-3932(95)00018-X
– year: 2020
  ident: B4
  article-title: Altered static and dynamic voxel-mirrored homotopic connectivity in subacute stroke patients: a resting-state fMRI study.
  publication-title: Brain Imaging Behav.
  doi: 10.1007/s11682-020-00266-x
– volume: 37
  start-page: 1209
  year: 2016
  ident: B22
  article-title: Major depressive disorder: findings of reduced homotopic connectivity and investigation of underlying structural mechanisms.
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.23097
– volume: 28
  start-page: 529
  year: 1990
  ident: B13
  article-title: Individual variability in cortical organization: Its relationship to brain laterality and implications to function.
  publication-title: Neuropsychologia
  doi: 10.1016/0028-3932(90)90032-J
– start-page: 971
  year: 2004
  ident: B12
  publication-title: Functional Integration in the Brain in Human Brain Function.
  doi: 10.1016/B978-012264841-0/50050-0
– volume: 110
  start-page: E3435
  year: 2013
  ident: B18
  article-title: Two distinct forms of functional lateralization in the human brain.
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.1302581110
– volume: 30
  start-page: 15034
  year: 2010
  ident: B60
  article-title: Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy.
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2612-10.2010
– volume: 12
  start-page: 1251
  year: 2018
  ident: B20
  article-title: Decreased interhemispheric coordination in the posterior default-mode network and visual regions as trait alterations in first-episode, drug-naive major depressive disorder.
  publication-title: Brain Imaging Behav.
  doi: 10.1007/s11682-017-9794-8
– volume: 34
  start-page: 537
  year: 1995
  ident: B1
  article-title: Functional connectivity in the motor cortex of resting human brain using echo-planar mri.
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.1910340409
– volume: 21
  start-page: 1636
  year: 2000
  ident: B7
  article-title: Mapping functionally related regions of brain with functional connectivity MR imaging.
  publication-title: Am. J. Neuroradiol.
– volume: 11
  start-page: 415
  year: 2006
  ident: B32
  article-title: The development of cerebral connections during the first 20–45 weeks’ gestation.
  publication-title: Semin. Fetal Neonatal. Med.
  doi: 10.1016/j.siny.2006.07.001
– volume: 91
  start-page: 5033
  year: 1994
  ident: B50
  article-title: A measure for brain complexity: relating functional segregation and integration in the nervous system.
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.91.11.5033
– volume: 37
  start-page: 2849
  year: 2016
  ident: B48
  article-title: A surface-based technique for mapping homotopic interhemispheric connectivity: development, characterization, and clinical application.
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.23214
– volume: 221
  start-page: 2735
  year: 2016
  ident: B51
  article-title: Variation in homotopic areas’ activity and inter-hemispheric intrinsic connectivity with type of language lateralization: an FMRI study of covert sentence generation in 297 healthy volunteers.
  publication-title: Brain Struct. Funct.
  doi: 10.1007/s00429-015-1068-x
– volume: 114
  start-page: 13278
  year: 2017
  ident: B43
  article-title: On the role of the corpus callosum in interhemispheric functional connectivity in humans.
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.1707050114
– volume: 9
  year: 2014
  ident: B55
  article-title: Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0099980
– volume: 4
  start-page: 484
  year: 1984
  ident: B25
  article-title: Intercorrelations of glucose metabolic ates between brain regions: application to healthy males in a state of reduced sensory input.
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.1984.73
– volume: 7
  start-page: 119
  year: 1998
  ident: B34
  article-title: Functional connectivity in single and multislice echoplanar maging using resting-state fluctuations.
  publication-title: Neuroimage
  doi: 10.1006/nimg.1997.0315
– volume: 240
  start-page: 171
  year: 2018
  ident: B10
  article-title: Analysis of voxel-mirrored homotopic connectivity in medication-free, current major depressive disorder.
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2018.07.037
– volume: 38
  start-page: 2026
  year: 2017
  ident: B54
  article-title: Heritability of white matter microstructure in late middle age: a twin study of tract-based fractional anisotropy and absolute diffusivity indices.
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.23502
– volume: 69
  start-page: 684
  year: 2011
  ident: B31
  article-title: Reduced interhemispheric resting state functional connectivity in cocaine addiction.
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.11.022
– volume: 254
  start-page: 46
  year: 2015
  ident: B29
  article-title: AICHA: an atlas of intrinsic connectivity of homotopic areas.
  publication-title: J. Neurosci. Methods
  doi: 10.1016/j.jneumeth.2015.07.013
– volume: 25
  year: 2020
  ident: B58
  article-title: Aberrant inter-hemispheric coordination characterizes the progression of minimal hepatic encephalopathy in patients with HBV-related cirrhosis.
  publication-title: NeuroImage Clin.
  doi: 10.1016/j.nicl.2020.102175
– volume: 187
  start-page: 74
  year: 2018
  ident: B39
  article-title: Modulation of intra- and inter-hemispheric connectivity between primary and premotor cortex during speech perception.
  publication-title: Brain Lang.
  doi: 10.1016/j.bandl.2017.12.002
– volume: 20
  start-page: 2852
  year: 2010
  ident: B46
  article-title: Longitudinal analysis of neural network development in preterm infants.
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhq035
– volume: 8
  year: 2013
  ident: B38
  article-title: An evaluation of the left-brain vs. right-brain hypothesis with resting state functional connectivity magnetic resonance imaging.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0071275
– volume: 28
  start-page: 6453
  year: 2008
  ident: B28
  article-title: Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum.
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0573-08.2008
– volume: 108
  start-page: 1299
  year: 2014
  ident: B56
  article-title: Increased interhemispheric resting-state in idiopathic generalized epilepsy with generalized tonic–clonic seizures: a resting-state fMRI study.
  publication-title: Epilepsy Res.
  doi: 10.1016/j.eplepsyres.2014.06.010
– volume: 7
  start-page: 76
  year: 2014
  ident: B3
  article-title: Topological organization of the human brain functional connectome across the lifespan.
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2013.11.004
– volume: 114
  start-page: 5521
  year: 2017
  ident: B15
  article-title: Heritability analysis with repeat measurements and its application to resting-state functional connectivity.
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.1700765114
– volume: 9
  start-page: 600
  year: 1986
  ident: B26
  article-title: Postnatal development of corticocortical connections.
  publication-title: Ital. J. Neurol. Sci.
  doi: 10.1523/jneurosci.09-02-00600.1989
– volume: 2015
  start-page: 1
  year: 2015
  ident: B35
  article-title: Decreased resting-state interhemispheric functional connectivity in Parkinson’s disease.
  publication-title: Biomed. Res. Int.
  doi: 10.1155/2015/692684
– volume: 141
  start-page: 1
  year: 2012
  ident: B24
  article-title: Decreased interhemispheric coordination in schizophrenia: a resting state fMRI study.
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2012.07.027
– volume: 17
  start-page: 587
  year: 1996
  ident: B8
  article-title: Effects of age upon interhemispheric EEG coherence in normal adults.
  publication-title: Neurobiol. Aging
  doi: 10.1016/0197-4580(96)00007-3
– volume: 112
  start-page: 6473
  year: 2015
  ident: B45
  article-title: Stable long-range interhemispheric coordination is supported by direct anatomical projections.
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.1503436112
– volume: 22
  start-page: 1455
  year: 2012
  ident: B49
  article-title: Laterality Patterns of Brain Functional Connectivity: Gender Effects.
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhr230
– volume: 3
  start-page: 547
  year: 2013
  ident: B40
  article-title: Resting-State Networks and the Functional Connectome of the Human Brain in Agenesis of the Corpus Callosum.
  publication-title: Brain Connect.
  doi: 10.1089/brain.2013.0175
SSID ssj0062842
Score 2.3769047
SecondaryResourceType review_article
Snippet Functional integration among neural units is one of the fundamental principles in brain organization that could be examined using resting-state functional...
Functional integration among neural units is one of the fundamental principles in brain organization that can be examined using resting-state functional...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 932
SubjectTerms Brain
Brain architecture
Brain mapping
Cerebral hemispheres
Cognition & reasoning
Cognitive ability
functional integration
Functional magnetic resonance imaging
Functional morphology
Hemispheric laterality
homotopic functional connectivity
Information processing
Integration
Investigations
left and right brain hemispheres
Medical imaging
Neural networks
Neuroimaging
Neuroscience
Neurosciences
resting-state functional connectivity
resting-state functional magnetic resonance imaging
Time series
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagvXBBhfIILchICIlDtIlfibmgLupqQaJC1SL1Fjl-lJVosmy3Qhz558w43qiLUE9RYiexMvb4G3vyfYS8EYWvwO3JXFlnc2F9lWvX-jzIUEhprDGRZ_bLmZp_E58v5EVacLtOaZVbnxgdtestrpFPYBqqkS5cyQ-rnzmqRuHuapLQuE_2wQXXEHztT0_Pvp5vfbEC5xv3OxX-GwTgfNiohLBMT0K37JCvm2Ful-ZsZ2KK_P3_A53_5k7emoxmB-RhQpH0ZDD7I3LPd4_J4UkHEfTVb_qWxrzOuGB-SP7MYOoaVvzop0QOAWd0OmRoUUCAdPGrp1MUi6Bz1H9DqgF__Z5uJUfpbN1fxYpzTN7rV0tLbz01JsvYQYaCRiEleo7kHd0ljVj2CVnMThcf53kSXsit0MUm9xVzzgBQ8TxAgGh1q5lDfibheGGYAZzEpLXOG-GsLKtgpTeFK1orAH94_pTsdX3nnxMqS17VQRmjiyA0HNvW6RYCYy-DK4PNyGT70RubSMlRG-NHA8EJmqmJZmrQTE00U0bejXesBkKOO-pO0Y5jPaTSjhf69WWTRmbDWZBa6to7ZYUPgJi5q2rFba1dwazLyPG2FzRpfMM7xt6YkddjMRgIt1tM5_sbrCOVgGi3UBl5NnSasSWclwxuFxmpdrrTTlN3S7rl98j-XQEAL1X94u5mHZEH-B1i2iE7Jnub9Y1_CfBp075KY-QvlPEeFw
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagXLggoDwCBRkJIXEITRw_YiSEuojVglQOaCv1Zjl-lJXapGy3gh7558w42dBFK06cosTjyPHYnm_syTeEvORFULDsiVw673Lugsq1b0IeRSyEsM7axDN7-EXOjvjnY3H85_fooQMvtrp2mE_qaHn65uf3q_cw4d-hxwn2dj-2ixaZtxlGaQEeuUlugV1SOE0P-XimIGEhZv1B5dZaG4Yp8fdvA51_x05eM0bTu-TOgCLpQa_2e-RGaO-T3YMWPOizK_qKprjOtGG-S35NwXT1O37000AOAXd00kdoUUCAdP6joxNMFkFnmP8NqQbCxVu6TjlKp8vuLAnOMHivO184eu2tKVjG9WkoaEqkRL8ieUd7QhOWfUDm04_zD7N8SLyQO66LVR4U894CUAlVBAfR6UYzj_xM3FeFZRZwEhPO-WC5d6JU0YlgC180jgP-CNVDstN2bXhMqCgrVUdprS4i13BtGq8bcIyDiL6MLiP76043biAlx9wYpwacE1STSWoyqCaT1JSR12ON856Q4x-yE9TjKIdU2ulBtzwxw8w0FYtCC10HLx0PERBz5VUtK1drXzDnM7K3HgVmPTwNgKIayeulyMiLsRgUhMcttg3dJcoIycHbLWRGHvWDZmxJVZUMqvOMqI3htNHUzZJ28S2xfysA4KWsn_yPb3tKbmNvpeBEtkd2VsvL8AxA1qp5nubOb3WHK2g
  priority: 102
  providerName: Scholars Portal
Title Functional Integration Between the Two Brain Hemispheres: Evidence From the Homotopic Functional Connectivity Under Resting State
URI https://www.ncbi.nlm.nih.gov/pubmed/33122984
https://www.proquest.com/docview/2448029865
https://www.proquest.com/docview/2456410406
https://pubmed.ncbi.nlm.nih.gov/PMC7566168
https://doaj.org/article/32f59598ed6c4ef0993d7863c89d02cd
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Ni9QwFA-yXryIun5U1yWCCB7KpPlq421HdhyFXWQZYW4lzYcOuO2yziIe_c99L-kMMyJ68ZLSJmnTvJfk95LH7xHyUrJQw7SnSu28K6ULdWl8F8qoIlPKOmsTz-zZuZ5_kh-WarkT6gt9wjI9cO64ieBRGWWa4LWTIQKgEb5utHCN8Yw7j7MvrHkbYyrPwRomXZ4PJcEEM5PYr3rk5ubox2UE31uEElf_nwDm736SOwvP7B65OyJGepJbep_cCv0DcnjSg7V8-YO-osmHM22OH5KfM1im8u4efT8SQcAdnWZvLApojy6-D3SKgSHoHGO9Ia1A-PaGbsKL0tn1cJkKztFRb7haObrz1uQY43LICZqCJtELJOroP9OEWx-Sxex08XZejkEWSicNW5eh5t5bACVBRDAGnekM98jFJL1gllvARFw554OV3qmqjk4FyzzrnASsEcQjctAPfXhCqKpE3URtrWFRGrh2nTcdGMFBRV9FV5DJptNbNxKQYxyMry0YIiimNompRTG1SUwFeb2tcZXJN_5Sdopy3JZD2uz0AJSpHZWp_ZcyFeRoowXtOJbhG2DBIlG9VgV5sc0GAeHRiu3DcINllJZg2TJdkMdZabYtEaLiUF0WpN5Tp72m7uf0qy-J6bsGsF3p5un_-Ldn5A72VnJE5EfkYH19E54DoFp3x-T29PT848VxGkOQvltWkJ7J5hfqxCaj
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwELZG9wAvCBiwwAAjARIP0VLHdmIkhFZY1bKtQlOR9hY5_jEqsaR0naY98gfxP3LnJNWK0N72VLVxUit3ubvPvnwfIW944jIIeyKWxpqYG5fFypYu9sInQmijdeCZPZrI0Xf-9UScbJA_3bsw2FbZxcQQqG1tcI18F9JQjnThUnya_4pRNQp3VzsJjcYtDtzVJUC284_jL2Dft4wN96efR3GrKhAbrpJl7DJmrYYs7FIP6MeoUjGL5EPcpolmGooAJoyxTnNrRD_zRjid2KQ0HJKrS-Gyd8gmTwHJ9MjmYH_y7bgL_RJifdhelfgqEmCBZl8UUKDa9dWsQnpwhq1kKmVreTDIBfyvxv23VfNa7hs-IPfbopXuNV72kGy46hHZ2qsAsJ9d0Xc0tJGG9fkt8nsImbJZYKTjlosCvtFB0xBGoeCk08uaDlCbgo5Qbg6ZDdz5B9opnNLhoj4LA0fYK1jPZ4Zeu2rozTGN6gUNuk30GLlCqlMaSufHZHobFnlCelVduW1CRT_Nci-1VonnCj7L0qoScLgT3va9ichud9ML03KgoxTHzwKwEJqpCGYq0ExFMFNE3q_OmDf8HzeMHaAdV-OQuTv8UC9OizYQFCnzQgmVOysNdx4K9NRmuUxNrmzCjI3ITucFRRtO4D9Wzh-R16vDYCDc3dGVqy9wjJAcwHUiI_K0cZrVTNK0z-B0HpFszZ3Wprp-pJr9CGTjGdT7fZk_u3lar8jd0fTosDgcTw6ek3t4T0LHI9shveXiwr2Aym1ZvmyfF0qKW35C_wJLvFso
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFD4anYR4QcCABQYYCZB4iJo6thMjIbSyVS2DapqGtLfI8WVUYknpOk175Gfx7zh2kmpFaG97ihI7iZVzfC72yfcBvGGJzdDs8Vhoo2OmbRZLU9rYcZdwrrRSAWf221SMv7MvJ_xkA_50_8L4ssrOJgZDbWrt18j76IZyDxcueN-1ZRGHe6NP81-xZ5DyO60dnUajIgf26hLTt_OPkz2U9VtKR_vHn8dxyzAQayaTZWwzaoxCj2xTh5mQlqWkxgMRMZMmiioMCCjX2ljFjOaDzGluVWKSUjN0tDbFx96BzQyToqQHm8P96eFR5wYE2v2w1Sr8b0mYFzR7pJgRyr6rZpWHCqe-rEymdM0nBuqA_8W7_5ZtXvODowdwvw1gyW6jcQ9hw1aPYGu3wuT97Iq8I6GkNKzVb8HvEXrNZrGRTFpcCjwjw6Y4jGDwSY4vazL0PBVk7KnnPMqBPf9AOrZTMlrUZ6Hj2NcN1vOZJteeGup0dMOAQQKHEznyuCHVKQlh9GM4vg2JPIFeVVd2GwgfpFnuhFIycUzisSyNLDEnt9yZgdMR9LuPXugWD93TcvwsMC_yYiqCmAovpiKIKYL3qzvmDRbIDX2HXo6rfh7FO1yoF6dFaxSKlDouucytEZpZh8F6arJcpDqXJqHaRLDTaUHRmhZ8x2oiRPB61YwC8js9qrL1he_DBcNEOxERPG2UZjWSNB1QvJ1FkK2p09pQ11uq2Y8APJ5h7D8Q-bObh_UK7uLMLL5OpgfP4Z7_JKH4ke5Ab7m4sC8wiFuWL9vpQqC45Qn6FzmkX10
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functional+Integration+Between+the+Two+Brain+Hemispheres%3A+Evidence+From+the+Homotopic+Functional+Connectivity+Under+Resting+State&rft.jtitle=Frontiers+in+neuroscience&rft.au=Xinhu+Jin&rft.au=Xinyu+Liang&rft.au=Gaolang+Gong&rft.au=Gaolang+Gong&rft.date=2020-10-02&rft.pub=Frontiers+Media+S.A&rft.eissn=1662-453X&rft.volume=14&rft_id=info:doi/10.3389%2Ffnins.2020.00932&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_32f59598ed6c4ef0993d7863c89d02cd
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1662-453X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1662-453X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1662-453X&client=summon