Inhibitory Receptor Diffusion Dynamics

The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. In this review article, we will outline the progression of understanding of receptor diffusion dynamics at the plasma membrane. We will discuss how regulation...

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Bibliographic Details
Published inFrontiers in molecular neuroscience Vol. 12; p. 313
Main Authors Maynard, Stephanie A, Triller, Antoine
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 19.12.2019
Frontiers Media S.A
Subjects
Cholesterol
Cytoskeleton
Diffusion
diffusion-trapping
GABAA receptor
gephyrin
glycine receptor
inhibitory synapse
Lipids
Neuroscience
Postsynapse
Proteins
Quantum dots
Regulation
single-particle tracking
Synaptic plasticity
Synaptic transmission
Viscosity
glycine receptor
diffusion-trapping
gephyrin
single-particle tracking
GABAA receptor
inhibitory synapse
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Summary:The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. In this review article, we will outline the progression of understanding of receptor diffusion dynamics at the plasma membrane. We will discuss how regulation of reversible trapping of receptor-scaffold interactions in combination with theoretical modeling approaches can be used to quantify these chemical interactions at the postsynapse of living cells.
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Reviewed by: Enrica Maria Petrini, Italian Institute of Technology (IIT), Italy; Jasmina N. Jovanovic, UCL School of Pharmacy, United Kingdom
Edited by: Shiva K. Tyagarajan, University of Zurich, Switzerland
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2019.00313