Rostro-Caudal and Caudo-Rostral Migrations in the Telencephalon: Going Forward or Backward?

The generation and differentiation of an appropriate number of neurons, as well as its distribution in different parts of the brain, is crucial for the proper establishment, maintenance and plasticity of neural circuitries. Newborn neurons travel along the brain in a process known as neuronal migrat...

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Published inFrontiers in neuroscience Vol. 11; p. 692
Main Authors Ruiz-Reig, Nuria, Studer, Michèle
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 21.12.2017
Frontiers Media S.A
Subjects
amygdala
Autism
Cell migration
cortical interneurons
Mental disorders
Nervous system
neuronal migration
Neurons
Neuroscience
Neurosciences
olfactory bulb
Prenatal development
Schizophrenia
Stem cells
Telencephalon
Transcription factors
Travel
amygdala
olfactory bulb
cortical interneurons
pallium
transcription factors
neuronal migration
telencephalon
subpallium
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Summary:The generation and differentiation of an appropriate number of neurons, as well as its distribution in different parts of the brain, is crucial for the proper establishment, maintenance and plasticity of neural circuitries. Newborn neurons travel along the brain in a process known as neuronal migration, to finalize their correct position in the nervous system. Defects in neuronal migration produce abnormalities in the brain that can generate neurodevelopmental pathologies, such as autism, schizophrenia and intellectual disability. In this review, we present an overview of the developmental origin of the different telencephalic subdivisions and a description of migratory pathways taken by distinct neural populations traveling long distances before reaching their target position in the brain. In addition, we discuss some of the molecules implicated in the guidance of these migratory paths and transcription factors that contribute to the correct migration and integration of these neurons.
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This article was submitted to Neurogenesis, a section of the journal Frontiers in Neuroscience
Edited by: Laura López-Mascaraque, Consejo Superior de Investigaciones Científicas (CSIC), Spain
Reviewed by: Fernando Garcia-Moreno, Achucarro Basque Center for Neuroscience, Spain; Nerea Moreno, Complutense University of Madrid, Spain
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2017.00692