Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx whic...

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Bibliographic Details
Published inBMB reports Vol. 40; no. 1; pp. 1 - 6
Main Authors Nagai, Hiroaki (The University of Tokyo, Tokyo, Japan), Noguchi, Takuya (The University of Tokyo, Tokyo, Japan), Takeda, Kohsuke (The University of Tokyo, Tokyo, Japan), Ichijo, Hidenori (The University of Tokyo, Tokyo, Japan), E-mail: ichijo@mol.f.u-tokyo.ac.jp
Format Journal Article
LanguageEnglish
Published Korea (South) 31.01.2007
Subjects
Animals
ASK1
Disease - etiology
ER stress
ESTRES
Humans
Immune System - physiology
innate immunity
MAP Kinase Kinase Kinase 5 - physiology
MAP Kinase Signaling System - physiology
MAPK
Models, Biological
Neurodegenerative Diseases - etiology
OXIDACION
OXIDATION
Oxidative Stress
OXYDATION
STRESS
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Summary:Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stress-related diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.
Bibliography:A50
2007003587
ISSN:1225-8687
1976-6696
0219-1024
DOI:10.5483/bmbrep.2007.40.1.001