Performance of the ESC 0/2h-algorithm using high-sensitivity cardiac troponin I in the early diagnosis of myocardial infarction

• Published in: The American heart journal Vol. 242; pp. 132 - 137
• Main Authors: Koechlin, Luca, Boeddinghaus, Jasper, Nestelberger, Thomas, Lopez-Ayala, Pedro, Wussler, Desiree, Shrestha, Samyut, Resa, Tobias, Wildi, Karin, Bakula, Adam, Frey, Simon, Miró, Òscar, Martin-Sanchez, F Javier, Strebel, Ivo, Gualandro, Danielle M, Eckstein, Friedrich S, Reuthebuch, Oliver, Keller, Dagmar I, Twerenbold, Raphael, Giménez, Maria Rubini, Mueller, Christian, Zimmermann, Tobias, Reichlin, Tobias, Christ, Michael, Puelacher, Christian, de Lavallaz, Jeanne du Fay, Potlukova, Eliska, Diebold, Matthias, Kawecki, Damian, Geigy, Nicolas, Rentsch, Katharina, Mitrovic, Sandra, Fuenzalida, Carolina, Glarner, Noemi, Morawiec, Beata, Munzk, Piotr, Breidthardt, Tobias, Freese, Michael, López, Beatriz, Calderón, Sofia, Adrada, Esther Rodriguez, Ganovská, Eva, Parenica, Jiri, von Eckardstein, Arnold, Campodarve, Isabel, Gea, Joaquim
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2021; Elsevier Limited
• Subjects: Accuracy; Algorithms; Architects; Biomarkers - blood; Calcium-binding protein; Cardiology; Cardiovascular disease; Early Diagnosis; Emergency medical care; Emergency medical services; Heart; Heart attacks; Humans; Laboratories; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Sensitivity; Troponin; Troponin I; Troponin I - blood; NSTEMI; CPO; hs-cTnI; ESC; NPV; CI; PPV; STEMI; IQR; ED
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1016/j.ahj.2021.08.008

The 2020 guidelines of the European Society of Cardiology (ESC) recommend a novel ESC 0/2h-algorithm as the preferred alternative to the ESC 0/1h-algorithm in the early triage for rule-out and/or rule-in of Non-ST-segment-elevation myocardial infarction (NSTEMI). The aim was to prospectively validate the performance of the ESC 0/2h-algorithm using the high-sensitivity cardiac troponin I (hs-cTnI) assay (ARCHITECT) in an international, multicenter diagnostic study enrolling patients presenting with acute chest discomfort to the emergency department.