Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4 + Cell Properties during Viral Infection
CD4 + T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4 + T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory ce...
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| Published in | Immunity (Cambridge, Mass.) Vol. 35; no. 4; pp. 633 - 646 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
28.10.2011
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | CD4
+ T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4
+ T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8
+ T cells, increased IL-7R expression was not a reliable marker of CD4
+ memory precursor cells. However, decreased Ly6C and T-bet (
Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C
loT-bet
int Th1 effector cells was virtually identical to mature memory CD4
+ T cells, indicating early maturation of memory CD4
+ T cell features in this subset during acute viral infection. This study provides a framework for memory CD4
+ T cell development after acute viral infection.
[Display omitted]
► Increased IL-7R expression does not mark CD4
+ memory precursor cells ► T-bet acts in a graded manner to regulate formation of Th1 and Tfh cell subsets ► Ly6C
loT-bet
int Th1 effector CD4
+ cells have enhanced longevity and recall responses ► Ly6C
loT-bet
int Th1 effector and memory CD4
+ cells share similar gene expression |
|---|---|
| AbstractList | CD4
+ T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4
+ T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8
+ T cells, increased IL-7R expression was not a reliable marker of CD4
+ memory precursor cells. However, decreased Ly6C and T-bet (
Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C
loT-bet
int Th1 effector cells was virtually identical to mature memory CD4
+ T cells, indicating early maturation of memory CD4
+ T cell features in this subset during acute viral infection. This study provides a framework for memory CD4
+ T cell development after acute viral infection.
[Display omitted]
► Increased IL-7R expression does not mark CD4
+ memory precursor cells ► T-bet acts in a graded manner to regulate formation of Th1 and Tfh cell subsets ► Ly6C
loT-bet
int Th1 effector CD4
+ cells have enhanced longevity and recall responses ► Ly6C
loT-bet
int Th1 effector and memory CD4
+ cells share similar gene expression CD4 + T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4 + T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8 + T cells, increased IL-7R expression was not a reliable marker of CD4 + memory precursor cells. However, decreased Ly6C and T-bet ( Tbx21 ) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C lo T-bet int Th1 effector cells was virtually identical to mature memory CD4 + T cells, indicating early maturation of memory CD4 + T cell features in this subset during acute viral infection. This study provides a framework for memory CD4 + T cell development after acute viral infection. CD4+T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4+T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8+T cells, increased IL-7R expression was not a reliable marker of CD4+memory precursor cells. However, decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6CloT-betintTh1 effector cells was virtually identical to mature memory CD4+T cells, indicating early maturation of memory CD4+T cell features in this subset during acute viral infection. This study provides a framework for memory CD4+T cell development after acute viral infection. CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4(+) T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8(+) T cells, increased IL-7R expression was not a reliable marker of CD4(+) memory precursor cells. However, decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C(lo)T-bet(int) Th1 effector cells was virtually identical to mature memory CD4(+) T cells, indicating early maturation of memory CD4(+) T cell features in this subset during acute viral infection. This study provides a framework for memory CD4(+) T cell development after acute viral infection. CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4(+) T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8(+) T cells, increased IL-7R expression was not a reliable marker of CD4(+) memory precursor cells. However, decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C(lo)T-bet(int) Th1 effector cells was virtually identical to mature memory CD4(+) T cells, indicating early maturation of memory CD4(+) T cell features in this subset during acute viral infection. This study provides a framework for memory CD4(+) T cell development after acute viral infection.CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4(+) T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8(+) T cells, increased IL-7R expression was not a reliable marker of CD4(+) memory precursor cells. However, decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C(lo)T-bet(int) Th1 effector cells was virtually identical to mature memory CD4(+) T cells, indicating early maturation of memory CD4(+) T cell features in this subset during acute viral infection. This study provides a framework for memory CD4(+) T cell development after acute viral infection. |
| Author | Marshall, Heather D. Poholek, Amanda C. Craft, Joe Rutishauser, Rachel Kaech, Susan M. Jung, Yong Woo Kleinstein, Steven H. Chandele, Anmol Parish, Ian A. Meng, Hailong Cui, Weiguo |
| AuthorAffiliation | 2 Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA 3 Interdepartmental Program in Computational Biology and Bioinformatics, Yale University School of Medicine, New Haven, CT 06520, USA 5 Department of Pharmacy, Korea University, Chungnam 339-700, Korea 4 Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA 6 Howard Hughes Medical Institute 1 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA |
| AuthorAffiliation_xml | – name: 2 Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA – name: 1 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – name: 3 Interdepartmental Program in Computational Biology and Bioinformatics, Yale University School of Medicine, New Haven, CT 06520, USA – name: 5 Department of Pharmacy, Korea University, Chungnam 339-700, Korea – name: 4 Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA – name: 6 Howard Hughes Medical Institute |
| Author_xml | – sequence: 1 givenname: Heather D. surname: Marshall fullname: Marshall, Heather D. organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 2 givenname: Anmol surname: Chandele fullname: Chandele, Anmol organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 3 givenname: Yong Woo surname: Jung fullname: Jung, Yong Woo organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 4 givenname: Hailong surname: Meng fullname: Meng, Hailong organization: Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 5 givenname: Amanda C. surname: Poholek fullname: Poholek, Amanda C. organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 6 givenname: Ian A. surname: Parish fullname: Parish, Ian A. organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 7 givenname: Rachel surname: Rutishauser fullname: Rutishauser, Rachel organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 8 givenname: Weiguo surname: Cui fullname: Cui, Weiguo organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 9 givenname: Steven H. surname: Kleinstein fullname: Kleinstein, Steven H. organization: Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 10 givenname: Joe surname: Craft fullname: Craft, Joe organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA – sequence: 11 givenname: Susan M. surname: Kaech fullname: Kaech, Susan M. email: susan.kaech@yale.edu organization: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22018471$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2011 Elsevier Inc. Copyright © 2011 Elsevier Inc. All rights reserved. Copyright Elsevier Limited Oct 28, 2011 2011 Elsevier Inc. 2011 |
| Copyright_xml | – notice: 2011 Elsevier Inc. – notice: Copyright © 2011 Elsevier Inc. All rights reserved. – notice: Copyright Elsevier Limited Oct 28, 2011 – notice: 2011 Elsevier Inc. 2011 |
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+ T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4... CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific... CD4+T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4+T... CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific... CD4 + T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4... |
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| SubjectTerms | Animals Antigens, Ly - genetics Antigens, Ly - immunology Cell Proliferation Gene expression Gene Expression Regulation Homeostasis Immunologic Memory Infections Lymphocytic choriomeningitis virus Mice Mice, Inbred C57BL T cell receptors T-bet Transcription Factor T-Box Domain Proteins - genetics T-Box Domain Proteins - immunology Th1 Cells - cytology Th1 Cells - immunology Th1 Cells - virology Viral infections |
| Title | Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4 + Cell Properties during Viral Infection |
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