Drugs as materials: valuing physical form in drug discovery

Traditionally, potency and selectivity (and to some extent metabolism) have been the key parameters to consider in the process of discovering new drug candidates. Recently, heads of research and CEOs have been learning a new reality: drugs can move around the body and act at the molecular level, but...

Full description

Saved in:
Bibliographic Details
Published inNature reviews. Drug discovery Vol. 3; no. 11; pp. 926 - 934
Main Authors Gardner, Colin R, Walsh, Christopher T, Almarsson, Örn
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.11.2004
Subjects
Chemistry, Pharmaceutical
Drug Design
Drug Industry
Drugs
Drugs, Investigational - chemistry
Evaluation
Patent law
Pharmaceutical industry
Pharmaceutical research
Product development
Technology application
United States
United Kingdom
Online AccessGet full text

Cover

More Information
Summary:Traditionally, potency and selectivity (and to some extent metabolism) have been the key parameters to consider in the process of discovering new drug candidates. Recently, heads of research and CEOs have been learning a new reality: drugs can move around the body and act at the molecular level, but the chemical and material properties of their physical form need to be identified and optimized for in vivo performance, reliable manufacture and the protection of intellectual property. This review discusses the challenge of pharmaceutical materials discovery, and suggests strategies for addressing the characterization and evaluation of physico-chemical and material properties in the drug discovery and development process.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:1474-1776
1474-1784
DOI:10.1038/nrd1550