The Role of the Vascular System in Degenerative Diseases: Mechanisms and Implications

• Published in: International journal of molecular sciences Vol. 25; no. 4; p. 2169
• Main Authors: Sheikh, Abdullah Md, Yano, Shozo, Tabassum, Shatera, Nagai, Atsushi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2024
• Subjects: Alzheimer's disease; Arthritis; Atherosclerosis; Biological Transport; Blood vessels; Blood-Brain Barrier - pathology; cardiovascular disease; Cerebrovascular Circulation; Chronic illnesses; chronic kidney disease; Chronic kidney failure; degenerative diseases; Development and progression; Disease prevention; endothelial dysfunction; Endothelium; Health aspects; Heart failure; Homeostasis; Humans; Hypertension; Inflammation; Kidney diseases; Macular degeneration; Metabolic syndrome; Mortality; Nervous system diseases; Neurodegeneration; neurodegenerative disease; Neurodegenerative Diseases - pathology; Nutrients; Osteoarthritis; Physiology; Public health; vascular system; Veins & arteries; cardiovascular disease; chronic kidney disease; neurodegenerative disease; age-related vascular changes; inflammation; degenerative diseases; vascular system; endothelial dysfunction
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25042169

Degenerative diseases, encompassing a wide range of conditions affecting various organ systems, pose significant challenges to global healthcare systems. This comprehensive review explores the intricate interplay between the vascular system and degenerative diseases, shedding light on the underlying mechanisms and profound implications for disease progression and management. The pivotal role of the vascular system in maintaining tissue homeostasis is highlighted, as it serves as the conduit for oxygen, nutrients, and immune cells to vital organs and tissues. Due to the vital role of the vascular system in maintaining homeostasis, its dysfunction, characterized by impaired blood flow, endothelial dysfunction, and vascular inflammation, emerges as a common denominator of degenerative diseases across multiple systems. In the nervous system, we explored the influence of vascular factors on neurodegenerative diseases such as Alzheimer's and Parkinson's, emphasizing the critical role of cerebral blood flow regulation and the blood-brain barrier. Within the kidney system, the intricate relationship between vascular health and chronic kidney disease is scrutinized, unraveling the mechanisms by which hypertension and other vascular factors contribute to renal dysfunction. Throughout this review, we emphasize the clinical significance of understanding vascular involvement in degenerative diseases and potential therapeutic interventions targeting vascular health, highlighting emerging treatments and prevention strategies. In conclusion, a profound appreciation of the role of the vascular system in degenerative diseases is essential for advancing our understanding of degenerative disease pathogenesis and developing innovative approaches for prevention and treatment. This review provides a comprehensive foundation for researchers, clinicians, and policymakers seeking to address the intricate relationship between vascular health and degenerative diseases in pursuit of improved patient outcomes and enhanced public health.