Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination

Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the condition...

Full description

Saved in:
Bibliographic Details
Published inOncoimmunology Vol. 2; no. 7; p. e24661
Main Authors Aarntzen, Erik HJG, Srinivas, Mangala, Schreibelt, Gerty, Heerschap, Arend, Punt, Cornelius JA, Figdor, Carl G, Oyen, Wim J, de Vries, I Jolanda M
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.07.2013
Landes Bioscience
Subjects
Author's View
dendritic cell
F MRI
imaging
immunotherapy
migration
migration
19F MRI
imaging
dendritic cell
immunotherapy
Online AccessGet full text

Cover

More Information
Summary:Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.24661