Myocardial Iron Deficiency in Hemodialysis-Dependent End-Stage Renal Disease Patients Undergoing Oral Iron Therapy

• Published in: Journal of the American College of Cardiology Vol. 70; no. 19; pp. 2455 - 2456
• Main Authors: Xu, Hua-yan, Yang, Zhi-gang, Li, Rui, Shi, Ke, Zhang, Yi, Li, Zhen-lin, Xia, Chun-chao, Peng, Wan-lin, Chen, Qing-yong, Guo, Ying-kun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.11.2017; Elsevier Limited
• Subjects: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Anemia, Iron-Deficiency - etiology; Anemia, Iron-Deficiency - metabolism; Cardiology; Cardiovascular; End-stage renal disease; Female; Hemodialysis; Humans; Iron; Iron - metabolism; Iron deficiency; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - therapy; Kidney transplantation; Liver; Male; Middle Aged; Myocardium - metabolism; Nutrient deficiency; Renal Dialysis; Young Adult; Canada; Calgary Alberta Canada; Alberta Canada; Germany
• ISSN: 0735-1097; 1558-3597; 1558-3597
• DOI: 10.1016/j.jacc.2017.09.013

Iron deficiency is the most common complication and the main cause of anemia in patients with hemodialysis-dependent end-stage renal disease (ESRD). [...]there is evidence indicating that SF and liver iron are poor indicators for tissue iron in some vital organs such as the heart (3). [...]quantitative assessment of myocardial iron levels in patients with hemodialysis-dependent ESRD may be useful for iron management, even for cases in which SF levels are within or higher than the normal range. Normal Control Subjects (n = 29) ESRD Without LV Dysfunction (n = 40) ESRD With LV Dysfunction (n = 21) Basal, ms 19.14 ± 1.97 24.53 ± 2.98∗ 26.13 ± 3.06∗† Middle, ms 20.17 ± 2.08 24.76 ± 3.25∗ 27.20 ± 3.77∗† Apical, ms 20.27 ± 3.71 23.70 ± 3.98∗ 25.24 ± 3.80∗† Global, ms 19.81 ± 1.94 24.27 ± 2.92∗ 26.07 ± 2.81∗† 1 H.S. Von, E.A. Jankowska, D.J. van Veldhuisen, Iron deficiency and cardiovascular disease, Nature Reviews Cardiology, Vol. 12, 2015, 659-669 2 R. Agarwal, J.W. Kusek, M.K. Pappas, A randomized trial of intravenous and oral iron in chronic kidney disease, Kidney International, Vol. 88, 2015, 905-914 3 P.A. Wahidiyat, F. Liauw, D. Sekarsari, Hematology, Vol. 22, 2017, 1-7 4 V. Melenovsky, J. Petrak, T. Mracek, Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis, Eur J Heart Fail, Vol. 19, 2017, 522-530