Tonotopic Organization in the Depth of Human Inferior Colliculus

Experiments in animal models indicate that inferior colliculus (IC), the primary auditory midbrain structure, represents sound frequency in a particular spatial organization, a tonotopy, that proceeds from dorsal and superficial to ventral and deeper tissue. Experiments are presented that use high-r...

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Published inFrontiers in human neuroscience Vol. 7; p. 586
Main Authors Ress, David, Chandrasekaran, Bharath
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 19.09.2013
Frontiers Media S.A
Subjects
Animal models
audition
Auditory discrimination
brainstem
fMRI
Frequency dependence
Functional magnetic resonance imaging
Inferior colliculus
Medical imaging
Mesencephalon
Neuroscience
Neurosciences
NMR
Noise
Nuclear magnetic resonance
Partial differential equations
Scanners
Sound
Statistical analysis
tonotopy
United States > US
audition
fMRI
inferior colliculus
midbrain
tonotopy
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Summary:Experiments in animal models indicate that inferior colliculus (IC), the primary auditory midbrain structure, represents sound frequency in a particular spatial organization, a tonotopy, that proceeds from dorsal and superficial to ventral and deeper tissue. Experiments are presented that use high-resolution, sparse-sampling functional magnetic resonance imaging (fMRI) at 3 T to determine if tonotopic gradients can be reliably measured in human IC using high-resolution fMRI. Stimuli were sequences of bandpass-filtered noise with different center frequencies, presented sequentially while fMRI data were collected. Four subjects performed an adaptive frequency-discrimination task throughout the experiment. Results show statistically significant tonotopic gradients within both ICs of all subjects. Frequency gradients as a function of depth were measured using surface-based analysis methods that make virtual penetrations into the IC tissue. This organization was evident over substantial portions of the IC, at locations that are consistent with the expected location of the central nucleus of IC. The results confirm a laminar tonotopy in the human IC at 3 T, but with a heterogeneous, patchy character. The success of these surface-based analysis methods will enable more detailed non-invasive explorations of the functional architecture of other subcortical human auditory structures that have complex, laminar organization.
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Edited by: Florian Beissner, Martinos Center for Biomedical Imaging, USA
Reviewed by: Elia Formisano, Maastricht University, Netherlands; Marc Schönwiesner, University of Montreal, Canada
This article was submitted to the journal Frontiers in Human Neuroscience.
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2013.00586