Human amniotic fluid antibodies protect the neonate against respiratory syncytial virus infection

• Published in: Journal of allergy and clinical immunology Vol. 138; no. 5; pp. 1477 - 1480.e5
• Main Authors: Jacobino, Shamir R., MS, Nederend, Maaike, BS, Hennus, Marije, MD, PhD, Houben, Michiel L., MD, PhD, Ngwuta, Joan O., BS, Viveen, Marco, BS, Coenjaerts, Frank E.J., PhD, Hack, C. Erik, MD, PhD, van Neerven, R.J. Joost, PhD, Graham, Barney S., MD, PhD, Bont, Louis, MD, PhD, Leusen, Jeanette H.W., PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016; Elsevier Limited
• Subjects: Allergy and Immunology; Amniotic Fluid - immunology; Animals; Antibodies, Viral - immunology; Celbiologie en Immunologie; Cell Biology and Immunology; Female; Humans; Immunoglobulins; Infant, Newborn; Infections; Leerstoelgroep Celbiologie en immunologie; Lungs; Medical research; Mice; Mice, Inbred BALB C; Proteins; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus, Human - immunology; Rodents; Studies; Viral infections; WIAS
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2016.06.001

[...]nothing is known on the presence of RSV nAbs in AF. [...]we investigated the presence of RSV nAbs in a panel of 28 AF samples from healthy term infants and hypothesized that (1) RSV nAbs are present in human AF and that (2) the presence of these antibodies in the lungs contributes to protection against RSV infection. In humans, it is impossible to distinguish between the protective effects of maternal antibodies acquired into the respiratory mucosa via serum and AF. [...]to investigate the specific contribution of antibodies in AF to protection against RSV infection, we performed a proof-of-concept study in mice by administering human AF into the lungs 1 day before RSV challenge.