Lack of Class I H-2 Antigens in Cells Transformed by Radiation Leukemia Virus is Associated with Methylation and Rearrangement of H-2 DNA

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 83; no. 12; pp. 4504 - 4508
• Main Authors: Meruelo, Daniel, Kornreich, Ruth, Rossomando, Anthony, Pampeno, Christine, Boral, Anthony, Silver, Jack L., Buxbaum, Joel, Weiss, Elizabeth H., Devlin, James J., Mellor, Andrew L., Flavell, Richard A., Pellicer, Angel
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.06.1986; National Acad Sciences
• Subjects: Animals; Biological and medical sciences; Cell differentiation, maturation, development, hematopoiesis; Cell physiology; Cell Transformation, Viral; DNA; DNA probes; DNA Restriction Enzymes; Fundamental and applied biological sciences. Psychology; Gels; Gene Expression Regulation; H 2 antigens; H-2 Antigens - genetics; Leukemia Virus, Murine; Leukemia, Experimental - genetics; Leukemia, Experimental - microbiology; Messenger RNA; Methylation; Mice; Molecular and cellular biology; Polymorphism, Genetic; Radiation leukemia virus; Recombination, Genetic; RNA, Messenger - genetics; T-Lymphocytes - physiology; Thymocytes; Thymoma; Transcription, Genetic; Tumors; Oncovirinae; Thymocyte; Radioinduced leukemia virus; Rodentia; Retroviridae; Gene expression; H-2-System; Cell transformation; Virus; Antigen; Vertebrata; Regulation(control); Mammalia; Mouse; Oncogenic virus; Type C oncovirus; Animal; Gene rearrangement; Methylation
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.83.12.4504

Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC DNA. These changes may play a role in host susceptibility to virus-induced leukemogenesis and accord with the notion that viral genomes play a regulatory function when they integrate adjacent to histocompatibility genes.