Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review

Oral lichen planus (OLP) is a chronic inflammatory disease that is characterized by the infiltration of T cells into the oral mucosa, causing the apoptosis of basal keratinocytes. OLP is a multifactorial disease of unknown etiology and is not solely caused by the malfunction of a single key gene but...

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Published inBiomolecules (Basel, Switzerland) Vol. 13; no. 11; p. 1646
Main Authors Kim, Tae-Jun, Kim, Yu Gyung, Jung, Won, Jang, Sungil, Ko, Hyoung-Gon, Park, Chan Ho, Byun, Jin-Seok, Kim, Do-Yeon
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.11.2023
Subjects
Antigens
Apoptosis
Care and treatment
circular RNA
Cytokines
Cytotoxicity
Dental research
Diabetes
Diagnosis
Disease
Epithelium
Etiology
Health aspects
Homeostasis
Human papillomavirus
Humans
Immunology
inflammation
Inflammatory diseases
Keratin
Keratinocytes
Keratinocytes - pathology
Lichen planus
Lichen Planus, Oral - diagnosis
Lichen Planus, Oral - genetics
Lichen Planus, Oral - therapy
long non-coding RNA
Lymphocytes
Lymphocytes T
microRNA
MicroRNAs
Mouth diseases
Mouth Mucosa - pathology
Non-coding RNA
oral lichen planus
Pathogenesis
Physiological aspects
RNA
T lymphocyte
T-Lymphocytes
South Korea
microRNA
long non-coding RNA
T lymphocyte
oral lichen planus
inflammation
circular RNA
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Summary:Oral lichen planus (OLP) is a chronic inflammatory disease that is characterized by the infiltration of T cells into the oral mucosa, causing the apoptosis of basal keratinocytes. OLP is a multifactorial disease of unknown etiology and is not solely caused by the malfunction of a single key gene but rather by various intracellular and extracellular factors. Non-coding RNAs play a critical role in immunological homeostasis and inflammatory response and are found in all cell types and bodily fluids, and their expression is closely regulated to preserve normal physiologies. The dysregulation of non-coding RNAs may be highly implicated in the onset and progression of diverse inflammatory disorders, including OLP. This narrative review summarizes the role of non-coding RNAs in molecular and cellular changes in the oral epithelium during OLP pathogenesis.
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ISSN:2218-273X
2218-273X
DOI:10.3390/biom13111646