Malignant pleural effusion from prostatic adenocarcinoma resolved with hormonal therapy

A 73-year-old man presented with dyspnea, right-sided pleural effusion, and bilateral pulmonary infiltrates. The pleural fluid revealed adenocarcinoma cells that stained positively for prostatic specific antigen (PSA), which confirmed this uncommon metastatic involvement from prostate cancer. The dy...

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Bibliographic Details
Published inChest Vol. 105; no. 5; p. 1577
Main Authors Carrascosa, M, Perez-Castrillon, J L, Mendez, M A, Cillero, L, Valle, R
Format Journal Article
LanguageEnglish
Published United States 01.05.1994
Subjects
Adenocarcinoma - complications
Adenocarcinoma - drug therapy
Adenocarcinoma - secondary
Aged
Flutamide - administration & dosage
Humans
Leuprolide - administration & dosage
Male
Pleural Effusion, Malignant - etiology
Pleural Neoplasms - complications
Pleural Neoplasms - drug therapy
Pleural Neoplasms - secondary
Prostatic Neoplasms - pathology
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Summary:A 73-year-old man presented with dyspnea, right-sided pleural effusion, and bilateral pulmonary infiltrates. The pleural fluid revealed adenocarcinoma cells that stained positively for prostatic specific antigen (PSA), which confirmed this uncommon metastatic involvement from prostate cancer. The dyspnea, effusion, and infiltrates disappeared after therapy with flutamide and leuprolide was started. This report demonstrates both the usefulness of immunocytochemical staining for PSA in ascertaining the origin of malignant pleural effusion in men and the effectiveness of the aforementioned endocrine therapy in such setting.
ISSN:0012-3692
DOI:10.1378/chest.105.5.1577