The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction
Food deprivation can rescue obesity and overweight-induced mood disorders, and promote mood performance in normal subjects. Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction, but little is known about the mechanism of calorie restriction-induced...
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Published in | Neuroscience bulletin Vol. 37; no. 9; pp. 1303 - 1313 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Singapore
Springer Singapore
01.09.2021
Springer |
Subjects | |
Online Access | Get full text |
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Summary: | Food deprivation can rescue obesity and overweight-induced mood disorders, and promote mood performance in normal subjects. Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction, but little is known about the mechanism of calorie restriction-induced mood modification. Previous studies have found that astrocytes modulate depressive-like behaviors. Inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is the predominant isoform in mediating astrocyte Ca
2+
signals and its genetic knockout mice are widely used to study astrocyte function
in
vivo
. In this study, we showed that deletion of IP3R2 blocked the antidepressant-like effect induced by calorie restriction.
In
vivo
microdialysis experiments demonstrated that calorie restriction induced an increase in ATP level in the medial prefrontal cortex (mPFC) in naïve mice but this effect disappeared in IP3R2-knockout mice, suggesting a role of astrocytic ATP in the calorie restriction-induced antidepressant effect. Further experiments showed that systemic administration and local infusion of ATP into the mPFC induced an antidepressant effect, whereas decreasing ATP by Apyrase in the mPFC blocked calorie restriction-induced antidepressant regulation. Together, these findings support a role for astrocytic ATP in the antidepressant–like effect caused by calorie restriction. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1673-7067 1995-8218 1995-8218 |
DOI: | 10.1007/s12264-021-00726-4 |