14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis

• Published in: The Lancet (British edition) Vol. 355; no. 9207; p. 901
• Main Authors: Irani, David N, Kerr, Douglas A
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 11.03.2000; Lancet; Elsevier Limited
• Subjects: 14-3-3 Proteins; Acute Disease; Biological and medical sciences; Body fluids; Cerebrospinal fluid. Meninges. Spinal cord; Enzyme Inhibitors - analysis; Humans; Medical sciences; Myelitis, Transverse - cerebrospinal fluid; Myelitis, Transverse - diagnosis; Nervous system (semeiology, syndromes); Neurological disorders; Neurology; Prognosis; Proteins; Proteins - analysis; Tyrosine 3-Monooxygenase; Cerebrospinal fluid disease; Human; Nervous system diseases; Biochemical analysis; Central nervous system disease; Immunoblotting assay; Evolution; Cerebrospinal fluid; Predictive factor; Spinal cord disease; Inflammatory disease; Transverse myelitis
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(99)04745-5

The eventual recovery of patients with acute transverse myelitis is variable and can be difficult to predict on the basis of the presenting clinical and radiographic features. We find that an early accumulation of the 14-3-3 protein occurs exclusively in the cerebrospinal fluid of patients who show little or no recovery of neurological function and therefore could serve as a helpful prognostic indicator in this disorder.