Constitutive and Stress-Induced Psychomotor Cortical Responses to Compound K Supplementation
Isolated ginsenoside metabolites such as Compound K (CK) are of increasing interest to consumer and clinical populations as safe and non-pharmacological means to enhance psychomotor performance constitutively and in response to physical or cognitive stress. Nevertheless, the influence of CK on behav...
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Published in | Frontiers in neuroscience Vol. 14; p. 315 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Research Foundation
08.04.2020
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
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Summary: | Isolated ginsenoside metabolites such as Compound K (CK) are of increasing interest to consumer and clinical populations as safe and non-pharmacological means to enhance psychomotor performance constitutively and in response to physical or cognitive stress. Nevertheless, the influence of CK on behavioral performance and EEG measures of cortical activity in humans is undetermined. In this double-blinded, placebo-controlled, counterbalanced within-group study, dose-dependent responses to CK (placebo, 160 and 960 mg) were assessed after 2 weeks of supplementation in nineteen healthy men and women (age: 39.9 ± 7.9 year, height 170.2 ± 8.6 cm, weight 79.7 ± 11.9 kg). Performance on upper- and lower-body choice reaction tests (CRTs) was tested before and after intense lower-body anaerobic exercise. Treatment- and stress-related changes in brain activity were measured with high-density EEG based on event-related potentials, oscillations, and source activity. Upper- (-12.3 ± 3.5 ms,
= 0.002) and lower-body (-12.3 ± 4.9 ms,
= 0.021) response times improved after exercise, with no difference between treatments (upper:
= 0.354; lower:
= 0.926). Analysis of cortical activity in sensor and source space revealed global increases in cortical arousal after exercise. CK increased activity in cortical regions responsible for sustained attention and mitigated exercise-induced increases in arousal. Responses to exercise varied depending on task, but CK appeared to reduce sensory interference from lower-body exercise during an upper-body CRT and improve the general maintenance of task-relevant sensory processes. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Jong-Min Kim, Seoul National University Bundang Hospital, South Korea This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Neuroscience Reviewed by: Hercules Rezende Freitas, UC Davis MIND Institute, United States; Dong Wook Kim, Konkuk University Medical Center, South Korea |
ISSN: | 1662-4548 1662-453X 1662-453X |
DOI: | 10.3389/fnins.2020.00315 |