Trimethylamine-N-oxide and Heart Failure With Reduced Versus Preserved Ejection Fraction

• Published in: Journal of the American College of Cardiology Vol. 70; no. 25; pp. 3202 - 3204
• Main Authors: Schuett, Katharina, Kleber, Marcus E., Scharnagl, Hubert, Lorkowski, Stefan, März, Winfried, Niessner, Alexander, Marx, Nikolaus, Meinitzer, Andreas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.12.2017; Elsevier Limited
• Subjects: Biomarkers - metabolism; Cardiology; Cardiovascular; Global Health; Heart diseases; Heart failure; Heart Failure - metabolism; Heart Failure - mortality; Heart Failure - physiopathology; Humans; Metabolites; Methylamines - metabolism; Pharmacogenomics; Prognosis; Risk factors; Stroke Volume - physiology; Survival Rate - trends; Trimethylamine; Trimethylamine-N-oxide

Trimethylamine-N-oxide (TMAO), a microbiota-associated metabolite, is associated with cardiovascular (CV) events in various populations (1), including patients with chronic heart failure (HF) (2,3).Additional adjustments for body mass index, New York Heart Association functional class, N-terminal pr...