Trimethylamine-N-oxide and Heart Failure With Reduced Versus Preserved Ejection Fraction

• Published in: Journal of the American College of Cardiology Vol. 70; no. 25; pp. 3202 - 3204
• Main Authors: Schuett, Katharina, Kleber, Marcus E., Scharnagl, Hubert, Lorkowski, Stefan, März, Winfried, Niessner, Alexander, Marx, Nikolaus, Meinitzer, Andreas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.12.2017; Elsevier Limited
• Subjects: Biomarkers - metabolism; Cardiology; Cardiovascular; Global Health; Heart diseases; Heart failure; Heart Failure - metabolism; Heart Failure - mortality; Heart Failure - physiopathology; Humans; Metabolites; Methylamines - metabolism; Pharmacogenomics; Prognosis; Risk factors; Stroke Volume - physiology; Survival Rate - trends; Trimethylamine; Trimethylamine-N-oxide
• ISSN: 0735-1097; 1558-3597; 1558-3597
• DOI: 10.1016/j.jacc.2017.10.064

Trimethylamine-N-oxide (TMAO), a microbiota-associated metabolite, is associated with cardiovascular (CV) events in various populations (1), including patients with chronic heart failure (HF) (2,3).Additional adjustments for body mass index, New York Heart Association functional class, N-terminal pro-brain natriuretic peptide (NT-proBNP), estimated glomerular filtration rate (eGFR), smoking, hypertension, coronary artery disease, diabetes mellitus, and atrial fibrillation (model 2) and further adjustment for high-sensitivity C-reactive protein (model 3) did not affect the significant association of TMAO with mortality.The authors also thank the LURIC study team members who were either temporarily or permanently involved in patient recruitment and sample and data handling; the laboratory staff at the Ludwigshafen General Hospital; and the Universities of Freiburg, Ulm, and Graz. 1 W.H. Tang, Z. Wang, B.S. Levison, Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk, N Engl J Med, Vol. 368, 2013, 1575-1584 2 M. Lever, P.M. George, S. Slow, Betaine and trimethylamine-n-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: an observational study, PLoS ONE, Vol. 9, 2014, e114969 3 M. Troseid, T. Ueland, J.R. Hov, Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure, J Intern Med, Vol. 277, 2015, 717-726 4 B.R. Winkelmann, W. Marz, B.O. Boehm, Rationale and design of the LURIC study-a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease, Pharmacogenomics, Vol. 2, 2001, S1-S73 5 J.J. McMurray, S. Adamopoulos, S.D. Anker, ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology.