Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine

• Published in: Human & experimental toxicology Vol. 22; no. 12; pp. 639 - 645
• Main Authors: Tasaduq, S A, Singh, K, Sethi, S, Sharma, S C, Bedi, K L, Singh, J, Jaggi, B S, Johri, R K
• Format: Journal Article
• Language: English
• Published: Thousand Oaks, CA SAGE Publications 01.12.2003; Arnold; Sage Publications Ltd
• Subjects: Administration, Oral; Alanine Transaminase - physiology; alpha-Tocopherol - administration & dosage; alpha-Tocopherol - pharmacology; Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Ascorbic Acid - administration & dosage; Ascorbic Acid - pharmacology; beta Carotene - administration & dosage; beta Carotene - pharmacology; Biological and medical sciences; Carbon Tetrachloride - administration & dosage; Carbon Tetrachloride - adverse effects; Carbon Tetrachloride - antagonists & inhibitors; Cell Survival - drug effects; Cell Survival - physiology; Cells, Cultured; Chemical and Drug Induced Liver Injury - drug therapy; chemoprotection; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Formazans - metabolism; General pharmacology; Glutathione - physiology; Hepatocytes - drug effects; Hepatocytes - enzymology; India; L-Lactate Dehydrogenase - physiology; Liver - drug effects; Liver - enzymology; Liver - pathology; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phyllanthus; Phytotherapy; Plant Preparations - pharmacology; Plant Preparations - therapeutic use; Plants, Medicinal - chemistry; Plants, Medicinal - drug effects; Rats; Silymarin - administration & dosage; Silymarin - pharmacology; Terminalia; Tinospora; Asia; India; Phyllanthus niruri; Phyllanthus emblica; antioxidant; Tinospora cordifolia; Terminalia chebula; Terminalia belerica; hepatoprotective; Hepatoprotector; Plant origin; Antioxidant; Biological activity; Mixture; Medicinal plant
• ISSN: 0960-3271; 1477-0903
• DOI: 10.1191/0960327103ht406oa

HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifoliahas been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro). HP-1 attenuated the serum toxicity as manifested in elevated levels of transaminases (glutamate oxaloacetate transaminase (GOT), and GPT) The anti-oxidative enzymes in liver (catalase and superoxide dismutase (SOD)) were restored to normal values after the oral administration of HP-1. HP-1 suppressed the formation of the superoxide anion radical and reduced CCl4 mediated lipid peroxidation (LPO). Silymarin and antioxidants (ascorbic acid,β-carotene and tocopherol) were used for comparison. The present study showed that HP-1 is a potential hepatoprotective formulation with an additional attribute of being anti-peroxidative.