Numb and Alzheimer's disease: the current picture

Twenty-three years ago, numb was identified as a critical regulator in Drosophila sensory organ precursor cell asymmetric divisions. Beyond the recently recognized role in carcinogenesis, Numb seems to be important in Alzheimer's disease. This assertion comes from the involvement in various pro...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neuroscience Vol. 6; p. 145
Main Authors Ntelios, Dimitrios, Berninger, Benedikt, Tzimagiorgis, Georgios
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 01.01.2012
Frontiers Media S.A
Subjects
Alzheimer's disease
Apoptosis
Carcinogenesis
Cell cycle
Insects
Kinases
Localization
Morphogenesis
Mutation
Neurogenesis
Neuropathology
Neuroscience
Notch signaling
Numb
NUMB protein
Pathogenesis
Peptides
Phosphorylation
Physiology
Proteins
synapse morphogenesis
neurogenesis
Alzheimer’s disease
notch signaling
numb
Online AccessGet full text

Cover

More Information
Summary:Twenty-three years ago, numb was identified as a critical regulator in Drosophila sensory organ precursor cell asymmetric divisions. Beyond the recently recognized role in carcinogenesis, Numb seems to be important in Alzheimer's disease. This assertion comes from the involvement in various processes such as synapse morphogenesis, amyloid precursor protein trafficking, notch signaling, and neurogenesis. The purpose of the present mini-review is to provide the current picture of Numb's participation in mechanisms underlying Alzheimer's disease pathogenesis and emphasize potential aspects for future research.
Bibliography:This article was submitted to Frontiers in Neurogenesis, a specialty of Frontiers in Neuroscience.
Reviewed by: Joshua Breunig, Cedars-Sinai Medical Center, USA; Mladen-Roko Rasin, Robert Wood Johnson Medical School, USA
Edited by: Angelique Bordey, Yale University School of Medicine, USA
ISSN:1662-4548
1662-453X
1662-4548
DOI:10.3389/fnins.2012.00145