Editorial: Cellular Mechanisms of Ototoxicity

On an evolutionary level, hearing loss reduces the perception of environmental auditory cues associated with beneficial or detrimental outcomes (e.g., localizing sounds associated with mating or predators). [...]the ability to hear well is crucial. Determining the structure-activity relationships (i...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in cellular neuroscience Vol. 12; p. 75
Main Authors Steyger, Peter S, Cunningham, Lisa L, Esquivel, Carlos R, Watts, Kelly L, Zuo, Jian
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 27.03.2018
Frontiers Media S.A
Subjects
Antibiotics
Apoptosis
Bacteria
Children & youth
Clinical trials
cochleotoxicity
Communication
Cytotoxicity
Deafness
Editorials
Hair
Hearing loss
Hearing protection
Language disorders
Medical research
Nervous system
Neuroscience
Neurosciences
Noise
otoprotection
Ototoxicity
Pharmaceuticals
Platinum
Predators
Quality of life
Structure-activity relationships
Tumor cells
vestibulotoxicity
United States > US
cochleotoxicity
otoprotection
vestibulotoxicity
ototoxicity
cytotoxicity
Online AccessGet full text

Cover

More Information
Summary:On an evolutionary level, hearing loss reduces the perception of environmental auditory cues associated with beneficial or detrimental outcomes (e.g., localizing sounds associated with mating or predators). [...]the ability to hear well is crucial. Determining the structure-activity relationships (i.e., how chemical structures affect the efficacy and/or safety) of candidate otoprotectants and their derivatives against ototoxicity and noise-induced hearing loss will accelerate the translation of candidate otoprotectants into clinical trials, similar to those described since these articles were published (Chowdhury et al., 2017; Kenyon et al., 2017). [...]candidate otoprotectants need to be screened to ensure they do not inadvertently protect bacteria or tumor cells from the crucial cytotoxic effects of aminoglycosides and platinum-based drugs. Neurosci. 7:84. doi: 10.3389/fnint.2013.00084 Peter S. Steyger1,2*, Lisa L. Cunningham3, Carlos R. Esquivel4, Kelly L. Watts4,5,6 and Jian Zuo7 * 1Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, United States * 2National Center for Rehabilitative Auditory Research, VA Portland Health Care System, Portland, OR, United States * 3National Institute on Deafness and Other Communication Disorders, Bethesda, MD, United States * 4Hearing Center of Excellence, J-9, Defense Health Agency, Joint Base San Antonio, San Antonio, TX, United States * 5Naval Submarine Medical Research Laboratory, Naval Submarine Base New London, Groton, CT, United States * 6zCore Business Solutions, Round Rock, TX, United States * 7Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, United States
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
Edited and reviewed by: Christian Hansel, University of Chicago, United States
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2018.00075