Chemobrain, Olfactory and Lifestyle Assessment in Onco-Geriatrics: Sex-Mediated Differences between Chemotherapy and Immunotherapy

A possible link between chemotherapy and cognitive impairment has been identified. In the literature, this condition is usually called chemobrain and can mostly affect some memory domain but can lead also to other cognitive impairments. Olfaction, which is known to be linked with cognitive domain an...

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Published inBrain sciences Vol. 12; no. 10; p. 1390
Main Authors Invitto, Sara, Leucci, Mariangela, Accogli, Giuseppe, Schito, Andrea, Nestola, Claudia, Ciccarese, Vincenzo, Rinaldi, Ross, Boscolo Rizzo, Paolo, Spinato, Giacomo, Leo, Silvana
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.10.2022
MDPI
Subjects
Brain research
Cancer therapies
Cell division
chemobrain
Chemosensory perception
Chemotherapy
Cognitive ability
cognitive impairment
frailty
Geriatrics
Immunotherapy
Medical diagnosis
Memory
Mental depression
Olfaction
Olfactory perception
Pain perception
chemobrain
frailty
olfaction
cognitive impairment
chemotherapy
immunotherapy
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Summary:A possible link between chemotherapy and cognitive impairment has been identified. In the literature, this condition is usually called chemobrain and can mostly affect some memory domain but can lead also to other cognitive impairments. Olfaction, which is known to be linked with cognitive domain and the nociception system, can also be affected by chemotherapy. The aim of this study was to investigate the main cognitive and olfactory abilities and the functional and nutritional state of a cohort of chemotherapy and immunotherapy onco-geriatric patients and control geriatrics subjects. Cognitive, olfactory, geriatric and nutritional assessments were performed through the Mini Mental State Examination (MMSE), Sniffin' Sticks Screening 12, G8 test and a questionnaire on the adherence of the Mediterranean diet, respectively. Our findings show a gender effect on the MMSE. Overall results indicate more pronounced impairments both at the cognitive and frailty level regardless of the type of therapy. On the other hand, the Sniffin' Sticks performances highlight a significant decrease in olfactory perception ability of subjects following immunotherapy. Significant correlations between olfactory performance and MMSE and G8 scores were also found, as well as between MMSE and G8 measures.
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ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci12101390