Neuropsychological Characteristics and Their Association with Higher-Level Functional Capacity in Parkinson's Disease

Background/Aims: Little is known about the relationship between cognitive functions and higher-level functional capacity (e.g. intellectual activity, social role, and social participation) in Parkinson's disease (PD). The purpose of this study was to clarify neuropsychological characteristics a...

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Published inDementia and geriatric cognitive disorders extra Vol. 5; no. 2; pp. 271 - 284
Main Authors Miura, Kayoko, Matsui, Mie, Takashima, Shutaro, Tanaka, Kortaro
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 19.06.2015
Karger Publishers
Subjects
Cognitive function
Higher-level functional capacity
Intellectual activity
Neuropsychological characteristics
Original
Original Research Article
Parkinsonߣs disease
Social identity
Social participation
Parkinsonߣs disease
Neuropsychological characteristics
Cognitive function
Higher-level functional capacity
Social identity
Social participation
Intellectual activity
Parkinson's disease
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Summary:Background/Aims: Little is known about the relationship between cognitive functions and higher-level functional capacity (e.g. intellectual activity, social role, and social participation) in Parkinson's disease (PD). The purpose of this study was to clarify neuropsychological characteristics and their association with higher-level functional capacity in PD patients. Methods: Participants were 31 PD patients and 23 demographically matched healthy controls. Neuropsychological tests were conducted. One year later, a questionnaire survey evaluated higher-level functional capacity in daily living. Results: The PD group scored significantly lower than the control group in all cognitive domains, particularly executive function and processing. Executive function, processing speed, language, and memory were significantly correlated with higher-level functional capacity in PD patients. Stepwise regression showed that only executive function (Trail Making Test-B), together with disease severity (HY stage), predicted the higher-level functional capacity. Conclusion: Our findings provide evidence of a relationship between executive function and higher-level functional capacity in patients with PD.
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ISSN:1664-5464
1664-5464
DOI:10.1159/000381333