Iron and other elements (Cu, Zn, Ca) contents in retina of rats during development and hereditary retinal degeneration
The retina as well as other tissues needs iron to survive, but modifications in iron metabolism have also been suggested to contribute to cerebral neurodegenerative diseases. Our study was intended to investigate iron distribution in the retina of normal rats and Royal College of Surgeons (RCS) rats...
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Published in | NUCL INSTRUM METHODS PHYS RES SECT B Vol. 181; no. 1; pp. 533 - 538 |
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Main Authors | , , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Elsevier B.V
01.07.2001
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The retina as well as other tissues needs iron to survive, but modifications in iron metabolism have also been suggested to contribute to cerebral neurodegenerative diseases. Our study was intended to investigate iron distribution in the retina of normal rats and Royal College of Surgeons (RCS) rats affected by hereditary degeneration of the photoreceptors at different developmental stages (35, 45 and 55 days after birth).
Iron (Fe) distribution was determined by proton induced X-ray emission (PIXE) microanalysis on retinal sections and compared to other tissues (cornea, liver, spleen) and to other elements (Cu, Zn, Ca). Elemental concentrations were determined in different retinal layers especially the photoreceptors, which are progressively altered and disappear in the RCS rats.
Iron is unevenly distributed throughout the rat retina. The highest concentration is observed in the choroid and the retinal pigmented epithelium and in the inner segments of photoreceptors. Iron content is lower in the outer segments but still significant. It increases during both the development and the disease at the level of the segments. This last localised iron increase can result in an overproduction of free radicals and be correlated with the photoreceptor cell loss. The distributions of other elements (Cu, Zn, Ca) revealed interesting temporal progressions. |
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Bibliography: | SourceType-Books-1 ObjectType-Book-1 content type line 25 ObjectType-Conference-2 SourceType-Conference Papers & Proceedings-2 |
ISSN: | 0168-583X 1872-9584 |
DOI: | 10.1016/S0168-583X(01)00484-0 |