Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine

The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The air...

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Published inJournal of innate immunity Vol. 10; no. 5-6; pp. 487 - 501
Main Authors Hartl, Dominik, Tirouvanziam, Rabindra, Laval, Julie, Greene, Catherine M., Habiel, David, Sharma, Lokesh, Yildirim, Ali Önder, Dela Cruz, Charles S., Hogaboam, Cory M.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2018
Subjects
Review
Review Article
Epithelial cells
Lung
Neutrophils
Innate lymphoid cells
Immune cells
Macrophages
Immunity
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Summary:The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment. Here, we summarize and discuss recent findings on pulmonary innate immunity and highlight key pathways relevant for biomarker and therapeutic targeting strategies for acute and chronic diseases of the respiratory tract.
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ISSN:1662-811X
1662-8128
DOI:10.1159/000487057