Imidocarb Dipropionate Lacks Efficacy against Theileria haneyi and Fails to Consistently Clear Theileria equi in Horses Co-Infected with T. haneyi
Control of , the primary cause of equine theileriosis, is largely reliant on acaracide use and chemosterilization with imidocarb dipropionate (ID). However, it is currently unknown if ID is effective against , the recently identified second causative agent of equine theileriosis, or if the drug main...
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Published in | Pathogens (Basel) Vol. 9; no. 12; p. 1035 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
10.12.2020
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | Control of
, the primary cause of equine theileriosis, is largely reliant on acaracide use and chemosterilization with imidocarb dipropionate (ID). However, it is currently unknown if ID is effective against
, the recently identified second causative agent of equine theileriosis, or if the drug maintains effectiveness against
in the presence of
co-infection. The purpose of this study was to address these questions using ID treatment of the following three groups of horses: (1) five
infected horses; (2) three
-
infected horses; and (3) three
-
infected horses. Clearance was first evaluated using nPCR for each
sp. on peripheral blood samples. ID failed to clear
in all three groups of horses, and failed to clear
in two of three horses in group two. For definitive confirmation of infection status, horses in groups two and three underwent splenectomy post-treatment. The
-nPCR-positive horses in group two developed severe clinical signs and were euthanized. Remaining horses exhibited moderate signs consistent with
. Our results demonstrate that ID therapy lacks efficacy against
, and
-
co-infection may interfere with ID clearance of
. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2076-0817 2076-0817 |
DOI: | 10.3390/pathogens9121035 |