Entropy in protein folding and in protein—protein interactions

The reduction of conformational entropy is a major barrier that has to be overcome in protein folding and binding. Changes in solvent entropy are also a major factor. Recent advances include clarification of the fundamental issues concerning the separation of entropy into components, the treatment o...

Full description

Saved in:
Bibliographic Details
Published inCurrent opinion in structural biology Vol. 7; no. 2; pp. 215 - 221
Main Authors Brady, G Patrick, Sharp, Kim A
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.1997
Subjects
Algorithms
Databases, Factual
Entropy
Protein Binding
Protein Conformation
Solvents
TI thermodynamic integration
eu entropy units
SAS solvent accessible surface
Online AccessGet full text

Cover

More Information
Summary:The reduction of conformational entropy is a major barrier that has to be overcome in protein folding and binding. Changes in solvent entropy are also a major factor. Recent advances include clarification of the fundamental issues concerning the separation of entropy into components, the treatment of association entropy in binding, and the role of size and shape effects in solvation entropy. Advances in the application of entropy calculations include an emerging consensus for estimates of backbone and sidechain entropy loss in protein folding via use of numerically intensive methods for sampling, and use of the expanding protein-structure database.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(97)80028-0