Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells

The ability of cancer cells to detach from the primary site and metastasize is the main cause of cancer- related death among all cancer types. Epithelial-to-mesenchymal transition (EMT) is the first event of the metastatic cascade, resulting in the loss of cell-cell adhesion and the acquisition of m...

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Bibliographic Details
Published inBiomolecules (Basel, Switzerland) Vol. 13; no. 11; p. 1604
Main Authors Atiya, Huda I, Gorecki, Grace, Garcia, Geyon L, Frisbie, Leonard G, Baruwal, Roja, Coffman, Lan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.11.2023
Subjects
Adipocytes
Breast cancer
Cancer
Cancer cells
Cell activation
Cell adhesion
Cell differentiation
Cell growth
Collagen
Colorectal cancer
Connective tissue cells
Development and progression
direct and indirect interaction
ECM remodeling
Enzymes
Epithelial cells
Epithelial-Mesenchymal Transition
Extracellular matrix
Extracellular Matrix - metabolism
Genotype & phenotype
Growth factors
Humans
Leukemia
mesenchymal stem cells
Metastases
Metastasis
MicroRNAs
Neoplasms - metabolism
Oncology, Experimental
Ovarian cancer
Phenotypes
Physiological aspects
Proteins
reprograming
Stem cells
Stromal cells
Transcription factors
Tumor Microenvironment
United States
ECM remodeling
direct and indirect interaction
mesenchymal stem cells
reprograming
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Summary:The ability of cancer cells to detach from the primary site and metastasize is the main cause of cancer- related death among all cancer types. Epithelial-to-mesenchymal transition (EMT) is the first event of the metastatic cascade, resulting in the loss of cell-cell adhesion and the acquisition of motile and stem-like phenotypes. A critical modulator of EMT in cancer cells is the stromal tumor microenvironment (TME), which can promote the acquisition of a mesenchymal phenotype through direct interaction with cancer cells or changes to the broader microenvironment. In this review, we will explore the role of stromal cells in modulating cancer cell EMT, with particular emphasis on the function of mesenchymal stromal/stem cells (MSCs) through the activation of EMT-inducing pathways, extra cellular matrix (ECM) remodeling, immune cell alteration, and metabolic rewiring.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13111604